PMID: 3383730Feb 1, 1988Paper

Relationship of body fat distribution pattern to atherogenic risk factors in NIDDM. Preliminary results

Diabetes Care
L Van GaalI De Leeuw

Abstract

Because recent knowledge indicates that the distribution of fat deposits in men may be a better predictor of cardiovascular disease than the degree of obesity alone, some risk factors for atherosclerosis were evaluated in 51 middle-aged men with non-insulin-dependent diabetes mellitus. Abdominal adiposity (waist/hip ratio, WHR) was related to parameters of metabolic control, lipid parameters, and known vascular complications in three different groups. In groups with abdominal obesity, mean annual hemoglobin A1 was significantly (P less than .01) higher than in patients without an abdominal fat distribution. Atherogenic index was significantly increased in the group with the highest WHR and high-density lipoprotein cholesterol (HDL-chol) levels were significantly decreased in both groups with upper-body fat distribution. The frequency of peripheral vascular disease, coronary ischemic heart disease, and hypertension was most prominent in diabetic subjects with an abdominal fat mass distribution. A highly significant (P less than .001) correlation was present between WHR and HDL-chol and WHR and the total-cholesterol/HDL-chol ratio; this significant correlation remains after correction for body mass index. A similar correlation co...Continue Reading

Citations

Apr 1, 1994·Diabetes/metabolism Reviews·B L WajchenbergA T Santomauro
Feb 5, 2000·Diabetes Research and Clinical Practice·I S IsmailB A Khalid
Feb 28, 2001·Diabetes, Obesity & Metabolism·K FujiokaUNKNOWN Sibutramine/Diabetes Clinical Study Group
Dec 1, 1989·Journal of the American College of Nutrition·L F Van GaalI H De Leeuw
Jun 1, 1991·Diabetic Medicine : a Journal of the British Diabetic Association·C BaynesR S Elkeles
Nov 12, 2013·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·A B SanthakumarI Singh
Jul 1, 2004·Revista española de cardiología·José A Gimeno OrnaDesirée P Portilla Córdoba
Aug 1, 1995·Journal of the American College of Nutrition·L Van GaalI De Leeuw
Apr 7, 2009·Arquivos brasileiros de endocrinologia e metabologia·Celma Lúcia Rocha Alves Ferreira, Márcia Gonçalves Ferreira
Jan 23, 2008·Arquivos brasileiros de endocrinologia e metabologia·Ana Carolina J VasquesSilvia Eloiza Priore
Apr 28, 2005·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·J I MannUNKNOWN Diabetes and Nutrition Study Group (DNSG) of the European Association
Aug 1, 1993·The American Journal of the Medical Sciences·M A Alpert, M W Hashimi

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