Relationship of cerebral blood flow to cardiac output, mean arterial pressure, blood volume, and alpha and beta blockade in cats

Journal of Neurosurgery
D H Davis, T M Sundt

Abstract

The relationship among cerebral blood flow (CBF), blood volume, cardiac output (CO), and mean arterial blood pressure (MABP) at varying levels of arterial CO2 tensions (PaCO2) were studied in 70 normal cats. The CBF was measured from the clearance curve of xenon-133 and CO with a thermal dilution catheter placed in the pulmonary artery. The CBF, CO, and MABP values varied appropriately with changes in PaCO2, confirming the reliability of the preparations and the presence of normal autoregulatory responses. Moderate hypovolemia that did not change MABP did, nevertheless, significantly decrease CO and CBF. In an effort to determine if this decrease in CO and CBF were coupled responses, the effects of beta stimulation, hypervolemia, and alpha and beta blockade were investigated. Propranolol, in a dosage insufficient to change MABP, decreased both CO and CBF. This agent abolished the CO response to elevations in PaCO2 but not the CBF response, making it unlikely that this CBF reduction resulted from impaired cerebral autoregulation. Isoproterenol, which, in contrast to propranolol, does not cross the normal blood-brain barrier, alone or in combination with phenoxybenzamine, produced a 38% and 72% increase in CO, respectively, witho...Continue Reading

References

Apr 1, 1978·Circulation Research·T J LeeJ A Bevan
Sep 1, 1978·Journal of Neurochemistry·T M SundtR A Van Dyke
Oct 1, 1978·Circulation Research·M J Purves
Jul 20, 1978·The New England Journal of Medicine·T M Sundt, J P Whisnant
Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M E RaichleL G Sharpe
Aug 1, 1977·Circulation·G GerstenblithM L Weisfeldt
Aug 1, 1976·The American Journal of Physiology·E T MacKenzieA M Harper
Aug 1, 1976·The American Journal of Physiology·E T MacKenzieA M Harper
Oct 11, 1975·Journal of Neurosurgery·T M Sundt
Apr 1, 1974·Circulation Research·S StrandgaardA M Harper
Sep 1, 1974·Circulation·M J KinneyV A DiScala
Feb 1, 1974·Journal of Applied Physiology·D J Warren, J G Ledingham
Jun 1, 1974·Circulation Research·N A Lassen
Jul 1, 1972·Archives of Neurology·A M HarperW B Jennett
Apr 1, 1971·The American Journal of Cardiology·W GanzH J Swan
Jul 1, 1968·The American Journal of Physiology·T W Langfitt, N F Kassell
Nov 1, 1966·Anesthesiology·R A TheyeJ D Michenfelder
Jan 1, 1954·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·G FEGLER
Nov 1, 1954·The American Journal of the Medical Sciences·J H MOYERS I MILLER
Sep 30, 1957·The Journal of Physiology·H F GRUNDY, F HOWARTH
Apr 1, 1959·Physiological Reviews·N A LASSEN
May 1, 1959·Circulation Research·A V GOODYERR H OSTBERG
Feb 1, 1950·The American Journal of Medicine·S S KETY
Jan 1, 1890·The Journal of Physiology·C S Roy, C S Sherrington

❮ Previous
Next ❯

Citations

Mar 1, 1985·Italian Journal of Neurological Sciences·A Spallone
May 1, 1989·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·T J Coonan
Mar 26, 1998·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·H Sakahashi
Jul 23, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S De RaedtJ De Keyser
Sep 1, 1983·Journal of Neurosurgery·G L CliftonR G Grossman
Jan 1, 1984·Journal of Neurosurgery·S HayashiR M Crowell
May 1, 1986·Journal of Neurosurgery·J J JafarS F Mullan
Jul 1, 1991·Journal of Neurosurgery·M L Levy, S L Giannotta
Jun 1, 1992·Journal of Neurosurgery·C A GillerD J Borchers
Jan 10, 2009·Neurological Research·Eric Michael DeshaiesA John Popp
Jul 1, 1984·Mayo Clinic Proceedings·D Chyatte, T M Sundt
Dec 1, 1985·Surgical Neurology·J I AusmanC S Son
Nov 1, 1985·The Journal of Surgical Research·T S KellerG W Kindt
May 4, 2004·Annales Françaises D'anesthèsie Et De Rèanimation·N Bruder, P Ravussin
Dec 27, 2005·Journal of the American College of Surgeons·Tim P NichollsAlexis B C Dang
Jun 1, 1993·Annals of Emergency Medicine·R D Fessler, F G Diaz
May 12, 2004·Critical Care Clinics·Paul C HébertLing Qun Hu
Jul 6, 2010·American Journal of Obstetrics and Gynecology·Ori NevoIsrael Thaler
Oct 14, 2016·Critical Care : the Official Journal of the Critical Care Forum·Cornelia GenbruggeCathy De Deyne
Feb 24, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Stephen M DombrowskiMark G Luciano
May 1, 1984·Stroke; a Journal of Cerebral Circulation·J A CapraroJ R Little
Sep 1, 1983·Stroke; a Journal of Cerebral Circulation·F P HolladayM W Roy
May 1, 1982·Stroke; a Journal of Cerebral Circulation·J R LittleN T Stowe
Apr 3, 1999·Stroke; a Journal of Cerebral Circulation·S A MayerL M Klebanoff
Sep 1, 1985·Stroke; a Journal of Cerebral Circulation·J C GrottaJ Spydell
May 1, 1988·Stroke; a Journal of Cerebral Circulation·O ShiokawaM Fujishima
Nov 1, 1988·Acta paediatrica Scandinavica·G GreisenH Lou

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.