Relationship of Change in Plasma Clozapine/N-desmethylclozapine Ratio with Cognitive Performance in Patients with Schizophrenia

Psychiatry Investigation
Royun ParkEuitae Kim

Abstract

The clozapine/N-desmethylclozapine (NDMC) ratio is proposed to be used as a predictor of cognitive performance in clozapine-treated patients, as its principal metabolite, NDMC, has an opposite action with clozapine on the cholinergic system. The aim of this study is to determine whether clozapine has influence on cognitive performance in accordance with changes in the clozapine/NDMC in patients with schizophrenia. The data of fifteen patients with schizophrenia, who had initial and follow-up assessments after starting clozapine treatment, were retrospectively collected. The assessments included clinical scale, cognitive battery, and pharmacological data including plasma concentrations of clozapine and NDMC. The data were analyzed with Pearson correlation and stepwise multiple regression analyses. ΔAttention/vigilance, Δsocial cognition, and Δcomposite score had a significant correlation with Δclozapine/NDMC ratio, while ΔWorking memory had correlation with Δclozapine concentration and ΔNDMC concentration, and Δsocial cognition had association with Δclozapine concentration. Multiple regression analysis showed that Δattention/vigilance had negative association with Δclozapine/NDMC ratio, Δworking memory had negative relation with...Continue Reading

References

Jan 1, 1988·European Journal of Clinical Pharmacology·Y F ChengJ Gabrielsson
Apr 3, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sudabeh Shirazi-SouthallGeorge G Nomikos
Jun 11, 2003·Archives of General Psychiatry·John M DavisIra D Glick
Nov 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Cyrille SurP Jeffrey Conn
Apr 7, 2007·Current Opinion in Psychiatry·Eileen M Joyce, Jonathan P Roiser
May 17, 2007·Current Drug Metabolism·Manoranjenni Chetty, Michael Murray
Jun 23, 2007·Pharmacology & Therapeutics·Jelveh LamehDouglas W Bonhaus
Jan 4, 2008·The American Journal of Psychiatry·Keith H NuechterleinStephen R Marder
Apr 11, 2008·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Jean-Marie DanionFabrice Berna
May 31, 2008·Journal of the American Geriatrics Society·Marci L ChewGeorges Gharabawi
Apr 14, 2009·Therapeutic Drug Monitoring·Aude JacobChristian Funck-Brentano
Jul 16, 2010·Journal of Clinical Psychopharmacology·Tarek K RajjiBenoit H Mulsant
Jul 30, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michael E Hasselmo, Martin Sarter
Oct 30, 2012·International Clinical Psychopharmacology·Anto P RajkumarKuruthukulangara S Jacob
Mar 4, 2014·The Journal of Clinical Psychiatry·Leslie Citrome
Apr 11, 2015·The American Journal of Psychiatry·Tarek K RajjiGary Remington
Jan 19, 2016·Lancet·Michael J OwenPreben B Mortensen
May 23, 2016·Schizophrenia Research·Silvana GalderisiUNKNOWN Italian Network for Research on Psychoses
Jun 28, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Frederick C NuciforaAkira Sawa
Feb 15, 2020·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Francesco Dal SantoEmilio Fernández-Egea

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here