Relationship of child IQ to parental IQ and education in children with fetal antiepileptic drug exposure.

Epilepsy & Behavior : E&B
Kimford J MeadorDavid W Loring

Abstract

Clinical trial designs need to control for genetic and environmental influences when examining cognitive outcomes in children for whom clinical considerations preclude randomization. However, the contributions of maternal and paternal IQ and education to pediatric cognitive outcomes are uncertain in disease populations. The Neurodevelopmental Effects of Antiepileptic Drugs (NEAD) Study is an ongoing prospective observational multicenter study in the United States and United Kingdom, which enrolled pregnant women with epilepsy to determine if differential long-term neurodevelopmental effects exist across four commonly used antiepileptic drugs. Here, we examined the relationship of IQ and education in both parents to child IQ at age 3 years. IQ and education for both parents were statistically correlated to child IQ. However, paternal IQ and education were not significant after accounting for maternal IQ effects. Because maternal IQ and education are independently related to child cognitive outcome, both should be assessed in studies investigating the effects of fetal drug exposures or other environmental factors that could affect the child's cognitive outcome.

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Citations

Jun 20, 2015·Epilepsy Research·Katherine Inoyama, Kimford J Meador
Jun 23, 2016·Epilepsy Currents·Alica M GoldmanUNKNOWN American Epilepsy Society (AES)/National Institute of Neurological Disorders and Stroke (NINDS) Epilepsy Benchmark Stewards
Apr 21, 2017·Neurochemical Research·Marissa Kellogg, Kimford J Meador
Oct 31, 2014·The Cochrane Database of Systematic Reviews·Rebecca BromleyAnthony G Marson
Aug 5, 2018·Journal of Neurology, Neurosurgery, and Psychiatry·Laura Fuglsang BechSøren Hagstrøm
Jul 13, 2013·Journal of the International Neuropsychological Society : JINS·Tricia L MerkleyWilliam M Perlstein
Oct 19, 2017·NeuroRehabilitation·D RiveraJ C Arango-Lasprilla
Oct 19, 2017·NeuroRehabilitation·D Rivera, J C Arango-Lasprilla
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Sep 28, 2017·NeuroRehabilitation·D RiveraJ C Arango-Lasprilla
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Dec 9, 2017·The Journal of Clinical Endocrinology and Metabolism·Stine Linding AndersenJørn Olsen
Mar 8, 2012·Current Opinion in Obstetrics & Gynecology

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