Relationship of comorbid personality disorders to prospective outcome in bipolar disorder.

Journal of Affective Disorders
R M PostMichael Rowe

Abstract

Introduction There is a high incidence of Axis II personality disorders (PDs) in patients with bipolar illness, but their influence on the prospectively measured course of bipolar disorder has been less well explicated. Methods 392 outpatients with bipolar disorder gave informed consent, completed the PDQ4 99 item personality disorder rating, and where clinically rated during at least one year of prospective naturalistic treatment. They were classified as Well on admission (N = 64) or Responders (N = 146) or Non-responders (N = 182) to treatment for at least six months. Results Patients who were positive for PDs were very infrequently represented in the category of Well on admission. In addition, patients with borderline, depressive, and schizoid PDs were significantly more likely to be Non-responders compared to Responders upon prospective naturalistic treatment in the network. Conclusions Patients with bipolar disorder and comorbid PDs were in general less likely to be Well from treatment in the community at network entry or to be a Responder to prospective treatment in the network. Therapeutic approaches to patients with PDs deserve specific study in an attempt to achieve a better long-term course of bipolar disorder.

References

May 1, 1990·Journal of the American Academy of Child and Adolescent Psychiatry·S P KutcherM Korenblum
Jun 1, 1990·Archives of General Psychiatry·M Zimmerman, W H Coryell
Aug 18, 1995·Journal of Affective Disorders·D CarpenterP J Wilner
May 1, 1996·Psychological Medicine·A J RushM H Trivedi
May 21, 2003·The Journal of Clinical Psychiatry·Gabriele S LeverichRobert M Post
Nov 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Charles B NemeroffMartin B Keller
Oct 4, 2005·The American Journal of Psychiatry·Mark ZimmermanIwona Chelminski
Jun 4, 2008·Archives of General Psychiatry·Thomas N CrawfordStephanie Kasen
Aug 25, 2009·Psychiatry Research·Lena Catherine QuiltyRobert Michael Bagby
Jul 30, 2010·The Journal of Clinical Psychiatry·Robert M PostWillem A Nolen
Oct 7, 2010·The Journal of Clinical Psychiatry·Robert M PostWillem A Nolen
Dec 15, 2010·Journal of Psychiatric Research·Tracie O AfifiJitender Sareen
Jul 11, 2014·Journal of Child and Adolescent Psychopharmacology·Tina R GoldsteinBoris Birmaher
Sep 26, 2017·International Journal of Bipolar Disorders·Georg RiemannRalph W Kupka
Jan 26, 2018·Bipolar Disorders·Robert M PostGerhard Hellemann
May 22, 2018·The Journal of Nervous and Mental Disease·Robert M PostMichael Rowe
Aug 3, 2018·Proceedings of the National Academy of Sciences of the United States of America·Robert M Post

❮ Previous
Next ❯

Citations

Oct 16, 2021·European Archives of Psychiatry and Clinical Neuroscience·Massimiliano BuoliUNKNOWN ISBD Italian Chapter Epidemiologic Group

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.