Relationship of Coronary Calcium on Standard Chest CT Scans With Mortality

JACC. Cardiovascular Imaging
Jan M Hughes-AustinJoachim H Ix

Abstract

The aim of this study was to determine the correlation between coronary artery calcium (CAC) scores on 3 mm electrocardiography (ECG)-gated computed tomography (CT) scans and standard 6 mm chest CT scans, and to compare relative strength of associations of CAC on each scan type with mortality risk. Coronary artery calcification predicts cardiovascular disease (CVD) and all-cause mortality, and is typically measured on ECG-gated 3 mm CT scans. Patients undergo standard 6 mm chest CTs for various clinical indications much more frequently, but CAC is not usually quantified. To better understand the usefulness of standard chest CTs to quantify CAC, we conducted a case-control study among persons who had both scan types. Between 2000 and 2003, 4,544 community-living individuals self- or physician-referred for "whole-body" CT scans, had 3 mm ECG-gated CTs and standard 6 mm chest CTs, and were followed for mortality through 2009. In this nested case-control study, we identified 157 deaths and 494 controls frequency matched (1:3) on age and sex. The Agatston method quantified CAC on both scan types. Unconditional logistic regression determined associations with mortality, accounting for CVD risk factors. Participants were 68 ± 11 years...Continue Reading

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Citations

Jan 19, 2016·JACC. Cardiovascular Imaging·Harvey S Hecht
May 3, 2016·Journal of Cardiovascular Computed Tomography·Veit SandfortDavid A Bluemke
Jul 23, 2016·Current Cardiology Reports·Barbora PitekovaMaros Ferencik
Jul 18, 2016·Diagnostic and Interventional Imaging·V Sandfort, D A Bluemke
Sep 30, 2016·The International Journal of Cardiovascular Imaging·Jacobo KirschCraig R Asher
Mar 17, 2017·Clinical Cardiology·Revathi BalakrishnanHarmony R Reynolds
Nov 14, 2018·Journal of Computer Assisted Tomography·Nagina MalguriaElliot K Fishman
Nov 7, 2018·Journal of Thoracic Imaging·Gastón A Rodríguez-GranilloPatricia Carrascosa
Feb 7, 2019·Insights Into Imaging·Maren KruegerAine Marie Kelly
Feb 26, 2019·Journal of Thoracic Imaging·Christopher L SchlettUNKNOWN Representing the International Workshop for Pulmonary Functional Imaging (IWPFI)
May 6, 2019·Current Treatment Options in Oncology·Michael E LayounMaros Ferencik
Jun 15, 2019·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Fernando U KayPrabhakar Rajiah
May 31, 2020·Journal of Cardiovascular Translational Research·Rafey A FerozeSalim S Hayek
Aug 30, 2019·Indian Journal of Anaesthesia·Swapnil Y ParabAstha Kanaparthi
Mar 25, 2020·Endocrinology and Metabolism·Bo Kyung KooMatthew A Allison
Mar 13, 2019·European Radiology·Yasunori NagayamaYasuyuki Yamashita
Jul 4, 2020·The European Respiratory Journal·Justin L Garner, Pallav L Shah
Jun 12, 2018·Chest·Surya P BhattUNKNOWN COPDGene Investigators
Apr 17, 2021·The International Journal of Cardiovascular Imaging·Pratik S VelangiPrabhjot Singh Nijjar
Sep 21, 2020·JACC. Cardiovascular Imaging·Philip GreenlandGeorge Thanassoulis
Jul 25, 2020·Journal of the American College of Cardiology·Yader SandovalAllan S Jaffe
Jul 15, 2021·Journal of Cardiovascular Medicine·Fabio FazzariUNKNOWN Humanitas COVID-19 Task Force

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