Relationship of creatine kinase, aspartate aminotransferase, lactate dehydrogenase, and proteinuria to cardiomyopathy in the owl monkey (Aotus vociferans)

Journal of Medical Primatology
Alfonso S GozaloRichard E Weller


The purpose of this study was to determine serum reference values for creatine kinase (CK), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) in captive-born and wild-caught owl monkeys to assess their usefulness for diagnosing myocardial disease. Blood samples were collected for CK, AST and LDH determinations. In addition, urine samples were collected and semiquantitative tests performed. There was no statistically significant difference between CK, AST and LDH when comparing both groups. However, when comparing monkeys with proteinuria to those without proteinuria, a statistically significant difference in CK value was observed (P = 0.021). In addition the CK/AST ratio revealed that 29% of the animals included in this study had values suggesting cardiac infarction. Grossly, cardiac concentric hypertrophy of the left ventricle and small, pitted kidneys were the most common findings. Microscopically, myocardial fibrosis, contraction band necrosis, hypertrophy and hyperplasia of coronary arteries, medium-sized renal arteries and afferent glomerular arteriolae were the most significant lesions, along with increased mesangial matrix and hypercellularity of glomeruli, Bowman's capsule and peritubular space fibroplasi...Continue Reading


Mar 1, 1991·Cardiovascular Drugs and Therapy·R Bolli
Apr 1, 1981·Veterinary Pathology·L V ChalifouxN W King
Jan 1, 1994·Journal of Medical Primatology·R E WellerH A Ragan
Nov 1, 1995·Journal of Medical Virology·L V AsherG D Young
Nov 19, 2002·International Journal for Parasitology·Sócrates HerreraMyriam Arévalo-Herrera
Dec 22, 2005·Infection and Immunity·Franca R JonesStephen E Walz
Jul 26, 2006·Pharmacotherapy·Robert L Talbert
Oct 7, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Orville A Smith, Cliff A Astley
Jan 1, 1990·American Journal of Primatology·Alfonso Gozalo, Enrique Montoya

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