PMID: 9439385Jan 24, 1998Paper

Relationship of endotoxin to tumor necrosis factor-alpha and interleukin-1 beta in children with otitis media with effusion

The Annals of Otology, Rhinology, and Laryngology
D N WillettT F DeMaria

Abstract

Sixty-five middle ear effusions and paired sera from 41 children with chronic otitis media with effusion were assayed for endotoxin and for tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) in order to establish whether a correlation exists between the concentrations of endotoxin and of these cytokines. Endotoxin concentration was determined by means of a chromogenic limulus amebocyte lysate assay, and the cytokine concentration by means of a quantitative enzyme-linked immunosorbent assay. Forty percent of the effusions had detectable levels of endotoxin, with a mean concentration of 2.9 +/- 7.8 endotoxin units per milligram of total protein. The mean concentration of TNF-alpha was 1.24 +/- 3.1 pg/mg total protein, and that of IL-1 beta was 18.79 pg/mg total protein. A strong, statistically significant correlation exists between the concentrations of endotoxin and TNF-alpha (r = .89) and IL-1 beta (r = .72). The data indicate that endotoxin may contribute to the pathogenesis of chronic otitis media with effusion by stimulating the sustained production of TNF-alpha and IL-1 beta in the middle ear.

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Citations

May 13, 2009·Clinical and Experimental Otorhinolaryngology·Steven K JuhnTina Huang
Oct 20, 2001·The Annals of Otology, Rhinology, and Laryngology·E J JeonT T Jung
Oct 29, 2004·The Laryngoscope·Kazuhiko MaedaGoro Mogi
May 10, 2003·Clinical and Diagnostic Laboratory Immunology·Shin KariyaKazunori Nishizaki
May 19, 2012·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Paulo Henrique WeckwerthMarco Antonio Húngaro Duarte
Jun 16, 2001·The Annals of Otology, Rhinology, and Laryngology·T WatanabeG Mogi
Nov 16, 2005·The Annals of Otology, Rhinology, and Laryngology·Ken-ichi HisamatsuMasami Homma
Feb 24, 2001·The Laryngoscope·L P SchousboeC B Pedersen
Feb 13, 2009·Current Allergy and Asthma Reports·Zdenek Pelikan
Jun 7, 2012·The Pediatric Infectious Disease Journal·Kim StolPeter W M Hermans
Mar 11, 2005·Expert Review of Anti-infective Therapy·Fotini-Maria ChantziDimitris A Kafetzis
Jul 23, 2014·Journal of the Association for Research in Otolaryngology : JARO·Nahid G RobertsonCynthia C Morton
Jun 17, 2015·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Beata Zielnik-Jurkiewicz, Wanda Stankiewicz-Szymczak
Aug 16, 2000·Clinical Otolaryngology and Allied Sciences·H KubbaJ P Birchall

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