Relationship of estrogen and pregnancy to calcium homeostasis in pseudohypoparathyroidism

The Journal of Clinical Endocrinology and Metabolism
N A Breslau, J E Zerwekh

Abstract

The relationship of estrogen administration and pregnancy to vitamin D metabolism and Ca homeostasis was examined in two young women with pseudohypoparathyroidism. Estrogen, which is believed to inhibit PTH-mediated bone resorption, caused a consistent dose-related reversible reduction of serum Ca in these patients. This finding supports the concept that PTH-mediated bone resorption may contribute to the maintenance of serum Ca in normocalcemic pseudohypoparathyroidism. Paradoxically, these two patients remained normocalcemic throughout pregnancy, a high estrogen state. They were studied during four pregnancies, and each time a similar pattern emerged. Despite a primary derangement of the renal 1 alpha-hydroxylase, serum 1,25-dihydrovitamin D [1,25-(OH)2D] concentration increased 2- to 3-fold, while the serum PTH level was nearly halved during pregnancy. After delivery, serum Ca and 1,25-(OH)2D decreased, and serum PTH rose appropriately. Placental synthesis of 1,25-(OH)2D may have contributed to the maintenance of normocalcemia in these patients.

Citations

Jul 19, 2005·Journal of Mammary Gland Biology and Neoplasia·Christopher S Kovacs
Mar 1, 1995·European Journal of Obstetrics, Gynecology, and Reproductive Biology·H J van den ElzenD E Grobbee
Mar 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·J Verhaeghe, R Bouillon
Sep 1, 1990·British Journal of Obstetrics and Gynaecology·N RasmussenL Hegedüs
May 26, 2012·Indian Journal of Endocrinology and Metabolism·Shriraam MahadevanR Bharath
Nov 1, 2001·Journal of Endocrinological Investigation·N Ozbey
Jul 11, 2012·Case Reports in Obstetrics and Gynecology·Anju SinghPinaki Dutta
Apr 22, 2015·Case Reports in Obstetrics and Gynecology·A D Herrera-MartínezJ M Quesada Gómez
Jun 1, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Naile GokkayaYusuf Karadeniz
Apr 13, 2017·Molecular and Cellular Endocrinology·James C Fleet
Nov 29, 2005·Endocrinology and Metabolism Clinics of North America·Christopher S Kovacs, Ghada El-Hajj Fuleihan
Nov 1, 1990·British Journal of Obstetrics and Gynaecology·G A FrommJ Ferraris
Dec 31, 1997·Endocrine Reviews·C S Kovacs, H M Kronenberg
Jun 17, 2010·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Vin Tangpricha
Dec 25, 2010·Critical Reviews in Clinical Laboratory Sciences·James C Fleet, Ryan D Schoch
Jul 18, 2019·Case Reports in Pathology·Rusella Mirza, Eric X Wei
Jul 9, 2011·Proceedings·Mousumi Som, Jeffrey S Stroup
Mar 10, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Aleksandra MedzaKrzysztof Sworczak

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