Relationship of frontal D(2/3) binding potentials to cognition: a study of antipsychotic-naive schizophrenia patients

The International Journal of Neuropsychopharmacology
Birgitte FagerlundBirte Y Glenthøj

Abstract

Studies of in vivo dopamine receptors in schizophrenia have mostly focused on D(2) receptors in striatal areas or on D(1) receptors in cortex. No previous study has examined the correlation between cortical dopamine D(2/3) receptor binding potentials and cognition in schizophrenia patients. The objective was to examine this relation in the frontal cortex in first-episode, drug-naive schizophrenia patients. Based on preclinical and pharmacological evidence, we specifically expected to find a relation between D(2/3) receptor binding potentials and set shifting. This was a cross-sectional, case-control study using single-photon emission computerized tomography with the D(2/3)-receptor ligand [(123)I]epidepride, co-registered with structural magnetic resonance imaging and correlated to cognitive measures. Participants were 24 antipsychotic-naive, first-episode schizophrenia patients and 20 healthy controls matched for gender and age. For patients, a significant linear correlation between D(2/3) BP(ND) and set shifting was found, while significant quadratic associations were observed for verbal fluency, planning and attention. For controls, the only significant association with D(2/3) BP(ND) was a quadratic partial correlation for s...Continue Reading

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Related Concepts

Prevalence Studies
Antipsychotic Effect
Cortex Bone Disorders
Adrenal Cortex Diseases
Tomography, Emission-Computed, Single-Photon
Dopamine D3 receptor
Magnetic Resonance Imaging
Schizophrenia
Dopamine D2 Receptor
Plasma Protein Binding Capacity

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