PMID: 7007887Feb 5, 1981Paper

Relationship of glicentin to proglucagon and glucagon in the porcine pancreas

Nature
A J MoodyS L Jensen

Abstract

We have previously isolated from porcine small intestine a peptide known as glicentin. The C-terminal portion of glicentin consists of the sequence of glucagon extended at its C terminus by an octapeptide, and differs slightly from the sequence of a proposed fragment of proglucagon. Glicentin-like material has been demonstrated in the pancreatic A cell, wherein it is located in the periphery of the secretory granules, whereas glucagon is located in the centre of the granules. To study the relationship of glicentin to the biosynthesis of glucagon, we have now investigated the glucagon-like and glicentin-like peptides in extracts and perfusates of the porcine pancreas. Our findings that a peptide with glicentin-like immunoreactivity, and intermediate in size between glicentin and glucagon, is secreted synchronously with glucagon suggest that this glicentin-related peptide is a major cleavage product of proglucagon.

References

Aug 23, 1977·Biochimica Et Biophysica Acta·H JacobsenF Sundby
Sep 1, 1976·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·F SundbyA J Moody
Aug 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·H S Tager, D F Steiner
May 1, 1980·The Biochemical Journal·J J Holst

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Citations

Aug 1, 1990·Cell and Tissue Research·I Salazar, C Vaillant
May 1, 1981·Regulatory Peptides·L Thim, A J Moody
Jan 1, 1981·Peptides·L Thim, A J Moody
Mar 1, 1987·Diabetes Research and Clinical Practice·A OhnedaY Maruyama
Sep 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·L C LopezG F Saunders
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·L ThimN P Fiil
May 1, 1983·Postgraduate Medical Journal·R G Long
Jan 1, 1997·Annual Review of Physiology·J J Holst
Dec 10, 1981·Nature·T W Schwartz, H S Tager
Jan 1, 1985·FEBS Letters·S P SheikhJ J Holst
Nov 1, 1989·Baillière's Clinical Endocrinology and Metabolism·A Aynsley-Green
Oct 1, 1986·General and Comparative Endocrinology·M E AbadJ H Rombout
Mar 23, 2005·Regulatory Peptides·Philip J Larsen, Jens Juul Holst
Aug 1, 1984·Metabolism: Clinical and Experimental·K TanakaH Yoshida
Oct 14, 1988·Diabetes Research and Clinical Practice·A OhnedaH Takahashi
Mar 1, 1987·Diabetes Research and Clinical Practice·A Ohneda
Jan 1, 1982·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·H L Lipscomb, J G Sharp
Jun 1, 1984·Bioscience Reports·J M ConlonH D Söling
Dec 5, 2017·The Journal of Clinical Investigation·Daniel J DruckerJens Juul Holst
Oct 12, 2007·Physiological Reviews·Jens Juul Holst
May 14, 2019·Frontiers in Endocrinology·Jens Juul Holst
Nov 2, 2019·International Journal of Molecular Sciences·Jens J Holst, Nicolai J Wewer Albrechtsen
Dec 26, 1996·Annals of the New York Academy of Sciences·J J HolstB Willms
Mar 1, 1989·The American Journal of Physiology·A OhnedaF Koizumi
Nov 27, 2019·Molecular Metabolism·T D MüllerM H Tschöp
May 1, 1986·The American Journal of Physiology·J M López-NovoaI Valverde
Jul 9, 2021·British Journal of Pharmacology·Jens Juul HolstKaare Villum Grunddal

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