PMID: 9531660Jun 13, 1998Paper

Relationship of HLA-DQA1 alleles and humoral antibody following measles vaccination

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
M S HayneyJ J Lipsky

Abstract

The human leukocyte antigen (HLA)-DQA1 locus is only moderately polymorphic compared to other HLA class II loci; however, we hypothesized that these polymorphisms could be important in determining the humoral antibody response to measles vaccine virus. The seroprevalence of measles antibody was determined in 881 school children who had been immunized with MMR-II at age approximately 15 months. All subjects resided in a geographic area with no circulating measles virus. The IgG antibody levels were determined by a measles-specific whole virus enzyme immunoassay (EIA) (BioWhittaker, Walkersville, MD). Subjects who were nonresponders (IgG seronegative or equivocal) (n = 46) and hyperresponders (upper 10th percentile of IgG levels of all subjects) (n = 64) were HLA-DQA1 typed using polymerase chain reaction with sequence-specific primers (PCR-SSP). The HLA-DQA1 allele frequencies, as well as homozygosity rates, were compared between the nonresponders and hyperresponders. The overall allele frequency distribution of alleles between the nonresponders and hyperresponders was significantly different (P = 0.05), with nonresponders having an excess of HLA-DQA1*05 alleles (P = 0.017) and hyperresponders having an excess of HLA-DQA1*01 all...Continue Reading

Citations

Feb 22, 2001·Human Immunology·G A PolandS B Moore
Jan 1, 2003·Human Immunology·Robert M JacobsonS Breanndan Moore
Oct 13, 2000·Allergy·S RemesJ Marshall
Jul 29, 2005·Journal of Clinical Pathology·J SmithD L Mattey
Jun 6, 2003·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·N DhimanG A Poland
May 14, 2003·Pharmacotherapy·Mary S HayneyRobert B Love
Jan 11, 2007·Tissue Antigens·Y J JuhnG A Poland
Feb 3, 2006·Expert Review of Vaccines·Inna G OvsyannikovaGregory A Poland
Apr 25, 2007·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Young J JuhnGregory A Poland
May 17, 2014·The Pediatric Infectious Disease Journal·Kwang Ha YooYoung J Juhn
Jun 5, 2004·Acta Paediatrica. Supplement·R M Jacobson, G A Poland

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