PMID: 15365276Sep 15, 2004Paper

Relationship of homocysteine with cardiovascular disease and blood pressure

The Journal of Clinical Hypertension
Rajani Dinavahi, Bonita Falkner

Abstract

Elevated plasma homocysteine (Hcy) concentration is considered a risk factor for cardiovascular disease and may also be associated with hypertension. Although links have been established between hyperhomocysteinemia and elevated risk for cardiovascular events, the precise role of plasma Hcy in cardiovascular disease is unclear. Plasma Hcy increases with aging and is associated with other health-related behaviors, including smoking and diet patterns. Both epidemiologic and longitudinal clinical investigations have investigated the possible contribution of plasma Hcy to cardiovascular disease, and most report an association of plasma Hcy with the risk for cardiovascular and cerebral events. Some reports describe a significant relationship between Hcy and blood pressure levels, as well as higher Hcy in hypertensives compared to normotensives. Other studies find that the effect of Hcy disappears following adjustment for other risk factors. Because Hcy cosegregates with other risk factors, it has been difficult to identify an independent effect of Hcy on cardiovascular disease or hypertension. Hcy can be modified to some extent by vitamin supplementation. Hcy reduction may have some benefit in reducing cardiovascular risk in some pa...Continue Reading

References

Aug 19, 1992·JAMA : the Journal of the American Medical Association·M J StampferC H Hennekens
Nov 15, 1995·JAMA : the Journal of the American Medical Association·O NygårdG Kvåle
Oct 4, 1995·JAMA : the Journal of the American Medical Association·C J BousheyA G Motulsky
Aug 1, 1995·International Journal of Epidemiology·E ArnesenJ E Nordrehaug
Apr 1, 1996·Nature Medicine·K S McCully
Apr 1, 1996·Journal of the American College of Nutrition·L Chasan-TaberM J Stampfer
Jun 11, 1997·JAMA : the Journal of the American Medical Association·I M GrahamG Andria
May 20, 1998·European Journal of Pediatrics·J D Finkelstein
Sep 30, 1998·American Journal of Hypertension·P FiorinaA Craveri
Apr 8, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S SirrsA Levin
Sep 4, 1999·Annals of Internal Medicine·J W EikelboomS Yusuf
Sep 12, 2000·Archives of Pediatrics & Adolescent Medicine·B FalknerH Kushner
Mar 10, 2001·The American Journal of Clinical Nutrition·P F JacquesJ Selhub
Feb 28, 2002·Cardiovascular Research·Jeanine E Roeters van LennepErnst E van der Wall
Jun 18, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Monica AcevedoDennis L Sprecher
Dec 14, 2002·American Journal of Epidemiology·Unhee Lim, Patricia A Cassano
Jan 18, 2003·Current Hypertension Reports·Coen van GuldenerCoen D A Stehouwer
Mar 12, 2003·The Journal of Clinical Endocrinology and Metabolism·Manisha ChandaliaScott M Grundy
May 17, 2003·Stroke; a Journal of Cerebral Circulation·Una B FallonGeorge Davey Smith
Aug 29, 2003·American Journal of Hypertension·Rajani DinavahiBonita Falkner
Sep 10, 2003·Transplantation Proceedings·J ManriqueA Purroy
Jan 30, 2004·Journal of the American Society of Nephrology : JASN·Elizabeth M WroneStephen P Fortmann
Jan 30, 2004·Journal of the American Society of Nephrology : JASN·Kamyar Kalantar-ZadehJoel D Kopple

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Citations

May 26, 2006·Journal of Human Hypertension·T S BowmanH D Sesso
Sep 11, 2010·Cardiovascular Diabetology·Paras K MishraSuresh C Tyagi
Apr 24, 2014·BMC Public Health·Theresa A NicklasVictor L Fulgoni
Feb 20, 2014·International Journal of Clinical Practice·F MartínezM J García-Fuster
Nov 6, 2013·Critical Reviews in Food Science and Nutrition·Bruno EbelPatrick Gervais
Apr 30, 2016·Scientific Reports·Yang XuanDao-Jun Hu
Jul 12, 2016·Canadian Journal of Physiology and Pharmacology·Sudhakar VeerankiSuresh C Tyagi
Oct 19, 2012·The Journal of Nutrition·Theresa A NicklasVictor L Fulgoni
Sep 8, 2018·Digestive Diseases and Sciences·Annalisa ChiocchettiUmberto Dianzani
Feb 13, 2007·The Journal of Cardiovascular Nursing·Lynne T Braun
Sep 24, 2019·Annals of Occupational and Environmental Medicine·Dukyun KangKyeongmin Kwak
May 29, 2020·Medical Hypotheses·Giovanni PontiAldo Tomasi

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