Relationship of hyperlipidemia to comorbidities and lung function in COPD: Results of the COSYCONET cohort

PloS One
Kathrin KahnertCOSYCONET consortium

Abstract

Although hyperlipidemia is common in COPD, its relationship to comorbidities, risk factors and lung function in COPD has not been studied in detail. Using the baseline data of the COSYCONET cohort we addressed this question. Data from 1746 COPD patients (GOLD stage 1-4; mean age 64.6 y, mean FEV1%pred 57%) were evaluated, focusing on the comorbidities hyperlipidemia, diabetes and cardiovascular complex (CVC; including arterial hypertension, cardiac failure, ischemic heart disease). Risk factors comprised age, gender, BMI, and packyears of smoking. The results of linear and logistic regression analyses were implemented into a path analysis model describing the multiple relationships between parameters. Hyperlipidemia (prevalence 42.9%) was associated with lower intrathoracic gas volume (ITGV) and higher forced expiratory volume in 1 second (FEV1) when adjusting for its multiple relationships to risk factors and other comorbidities. These findings were robust in various statistical analyses. The associations between comorbidities and risk factors were in accordance with previous findings, thereby underlining the validity of our data. In conclusion, hyperlipidemia was associated with less hyperinflation and airway obstruction in p...Continue Reading

References

Jul 4, 2001·JAMA : the Journal of the American Medical Association·M A AlbertUNKNOWN PRINCE Investigators
Jul 9, 2005·American Journal of Respiratory and Critical Care Medicine·Ji-Hyun LeeSang-Do Lee
Jan 19, 2007·Respiratory Medicine·Ivo van der LeeJan-Willem J Lammers
May 12, 2007·International Journal of Clinical Practice·H E BaysUNKNOWN SHIELD Investigators' Group
May 6, 2008·Proceedings of the American Thoracic Society·Wissam M ChatilaBarry J Make
Jan 13, 2009·American Journal of Respiratory and Critical Care Medicine·Nathalie LeoneMahmoud Zureik
Dec 7, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Masashi BandoYukihiko Sugiyama
May 9, 2012·American Journal of Respiratory and Critical Care Medicine·Miguel DivoUNKNOWN BODE Collaborative Group
Jun 30, 2012·The European Respiratory Journal·Philip H QuanjerUNKNOWN ERS Global Lung Function Initiative
May 7, 2013·The American Journal of the Medical Sciences·Ehimare AkhabueConstantine E Kosmas
Apr 15, 2014·Respiratory Physiology & Neurobiology·Pierachille SantusMatteo Pecchiari
Apr 23, 2014·Prevention Science : the Official Journal of the Society for Prevention Research·Rick H Hoyle, Nisha C Gottfredson
Oct 10, 2014·PloS One·Wei-Liang ChenTao-Chun Peng
Oct 25, 2014·BMC Pulmonary Medicine·Craig P HershUNKNOWN COPDGene and ECLIPSE Investigators
Nov 2, 2015·Respiratory Investigation·Netsanet A NegewoPeter G Gibson
Apr 26, 2016·Respiratory Medicine·Annika KarchUNKNOWN COSYCONET Study Group

❮ Previous
Next ❯

Citations

Mar 29, 2019·Respiratory Research·Peter AlterRudolf A Jörres
Jul 1, 2020·Scientific Reports·F C TrudzinskiUNKNOWN COSYCONET consortium
Jan 22, 2020·Respiratory Research·K KahnertR A Jörres
Sep 29, 2020·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Ivona MarkelićAndrea Vukić Dugac
Oct 5, 2018·Deutsches Ärzteblatt International·Jana GrafJoachim H Ficker
Nov 19, 2019·Respiratory Medicine·Sarah Marietta von SiemensUNKNOWN Names of participating study nurses
May 6, 2020·Respiration; International Review of Thoracic Diseases·Christina KellererRudolf A Jörres

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT01245933

Software Mentioned

AMOS
SPSS Statistics
COSYCONET

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.