Relationship of immunosuppression to Epstein-Barr viral load and lymphoproliferative disease in pediatric heart transplant patients

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Stephan SchubertPetra Reinke

Abstract

Post-transplant lymphoproliferative disease (PTLD) is a severe complication in transplant recipients. Detection of increased Epstein-Barr viral (EBV) load in the peripheral blood acts as a surrogate marker for increased risk of PTLD development. We prospectively monitored EBV load, immunosuppression and PTLD in pediatric heart transplant (HTx) patients to determine risk factors for an increased EBV load and risk of PTLD. Forty-one pediatric heart transplant recipients were included and underwent prospective monitoring of their immunosuppression and ethylene-diamine tetraacetic acid (EDTA) blood sampling for EBV load (copies/microg DNA) measurement using quantitative real-time polymerase chain reaction (PCR; TaqMan) during January 2001 to December 2006. EBV load was measurable in 70% and was significantly increased (>2,000 copies/microg DNA) in 35% of the patients, with a median EBV load of 5,100 (range 0 to 50,665 copies/microg DNA). Increased EBV load was detected in patients receiving CsA-azathioprine or more than two doses of anti-thymocyte globulin (ATG) and in those <10 years of age, without any significant differences in CsA blood levels. Lowest or negative EBV load was measured in patients receiving CsA-mycophenolate mof...Continue Reading

References

Jan 1, 1990·Medical Microbiology and Immunology·M E LamyJ B Otte
Dec 31, 1998·Springer Seminars in Immunopathology·M A Nalesnik
Apr 30, 1999·Transplantation·Y DrorS Weitzman
Jan 29, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·N R KriegerC O Esquivel
Apr 14, 2000·American Journal of Respiratory and Critical Care Medicine·A H CohenM R DeBaun
Mar 16, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·E A. VerschuurenJ M. Middeldorp
Mar 16, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·M A. MaloufA Glanville
Mar 16, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·R HirschC E. Canter
May 2, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Monique A MaloufAllan R Glanville
Oct 12, 2002·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Bettina H AultRobert J Wyatt
Aug 2, 2003·Pediatric Transplantation·Rimas J OrentasDavid A Margolis
Jan 22, 2004·Journal of Pediatric Gastroenterology and Nutrition·Rainer GanschowMartin Burdelski
Mar 27, 2004·Intervirology·Chiara MerlinoRossana Cavallo
Jul 1, 2004·Transplant Infectious Disease : an Official Journal of the Transplantation Society·R ScheenstraH J Verkade
Dec 15, 2004·Chest·Michael E HalkosAnthony A Gal
Feb 15, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Barbara SavoldoJohn A Goss
Mar 12, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Jennifer TrofeE Steve Woodle
Jun 14, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Rishi Raj, Adaani E Frost
Oct 12, 2005·Journal of Pediatric Hematology/oncology·Markus G SeidelChristina Peters
Dec 21, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Christian BendenMartin J Elliott
Mar 2, 2006·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Michael RossDaniel Bernstein

❮ Previous
Next ❯

Citations

Aug 12, 2009·International Journal of Hematology·Hideaki OhtaKeiichi Ozono
Mar 1, 2011·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Michael HueblerRoland Hetzer
Dec 12, 2012·Transplantation·Tilmann SchoberBritta Maecker-Kolhoff
Aug 16, 2013·World Journal of Gastroenterology : WJG·María Gómez-GarcíaEduardo Redondo-Cerezo
Jan 1, 2011·Revista brasileira de hematologia e hemoterapia·Luciana Cristina Fagundes GequelinCarmem M Bonfim
Aug 23, 2011·Pediatric Clinics of North America·Margaret L Stuber
Sep 14, 2010·Transplantation Proceedings·R CavalloM Bergallo
May 19, 2010·Child and Adolescent Psychiatric Clinics of North America·Margaret L Stuber
Apr 8, 2010·Pediatric Clinics of North America·Thomas G GrossAngela Punnett
Apr 17, 2010·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Barbara Gärtner, Jutta K Preiksaitis
Feb 10, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·José H F PalmaEnio Buffolo
Oct 31, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·David L MurrayDylan V Miller
Jun 17, 2008·The Journal of Molecular Diagnostics : JMD·Margaret L Gulley, Weihua Tang
Mar 4, 2009·Pediatric Transplantation·Vikas Dharnidharka, Sushil Gupta
Jun 21, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Andreas O DoeschThomas J Dengler
Oct 18, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R ChinnockUNKNOWN Pediatric Heart Transplant Study
Aug 23, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Marijke Nynke BoersmaPeter Alexander Marcel de Vries
Nov 21, 2012·Reviews in Medical Virology·Daniel C BrennanBjörn Nashan
Oct 26, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R NaC M Vajdic
Nov 5, 2014·Transplant International : Official Journal of the European Society for Organ Transplantation·Andreas ZuckermannMarkus J Barten
Apr 24, 2010·Alimentary Pharmacology & Therapeutics·M A SmithJ D Sanderson
Jan 31, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·R San-JuanP Meylan
Nov 1, 2013·Clinical & Developmental Immunology·Martin MynarekBritta Maecker-Kolhoff
Aug 16, 2011·Transplantation Proceedings·G IppolitiV Nieswandt
Mar 23, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Cedric ManlhiotAnne I Dipchand
Sep 10, 2011·Journal of Virological Methods·Francesca GattoMauro S Malnati
Aug 23, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M A AlDabbaghS Husain
May 18, 2019·Archives of Disease in Childhood·Zdenka Reinhardt
Mar 10, 2017·World Journal of Gastroenterology : WJG·Ahad EshraghianSeyed Ali Malek-Hosseini
May 20, 2020·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Devika GuptaTathagata Chatterjee
Dec 20, 2018·Immunological Reviews·Noriko MitsuikiBodo Grimbacher

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.