Relationship of insulin, glucose, leptin, IL-6 and TNF-α in human breast milk with infant growth and body composition.

Pediatric Obesity
D A Fields, E W Demerath

Abstract

Numerous appetite, growth, obesity-related hormones and inflammatory factors are found in human breast-milk, but there is little evidence on their relationship with infant body composition. OBJECTVIE: The purpose of the present cross-sectional pilot study was to assess the cross-sectional associations of appetite-regulating hormones and growth factors (leptin, insulin and glucose) and inflammatory factors (interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α)) in human breast-milk with infant size, adiposity, and lean tissue at 1-month of age in healthy term infants. Human breast-milk was collected from nineteen exclusively breast-feeding mothers using one full breast expression between 8:00 and 10:00 a.m. The milk was then mixed, aliquoted, stored at -80°C and then centrifuged to remove the milk fat, prior to analyses using commercially available immunoassay kits; milk analytes were natural log transformed prior to analysis. Infant body composition was assessed using a Lunar iDXA v11-30.062 scanner (Infant whole body analysis enCore 2007 software, GE, Fairfield, CT). Maternal pre-pregnancy BMI was positively associated with milk leptin concentration (P = 0.0027), and so maternal-BMI-adjusted Spearman correlations were e...Continue Reading

References

Apr 1, 1989·Journal of the American College of Nutrition·L Jovanovic-PetersonC M Peterson
Nov 1, 1986·Journal of Pediatric Gastroenterology and Nutrition·C Garza, N F Butte
Jun 1, 1984·The Journal of Clinical Endocrinology and Metabolism·R C BaxterJ R Turtle
Jan 1, 1995·Journal of Pediatric Gastroenterology and Nutrition·R G JensenM Murtaugh
Nov 18, 1997·Early Human Development·P M Emmett, I S Rogers
Dec 17, 1997·The Journal of Clinical Endocrinology and Metabolism·X CasabiellF F Casanueva
Apr 15, 2000·Nature·M W SchwartzD G Baskin
Jul 1, 1996·Journal of Mammary Gland Biology and Neoplasia·A S GoldmanF C Schmalstieg
Jul 16, 2002·The British Journal of Nutrition·Leon R MitoulasPeter E Hartmann
Apr 12, 2003·Obesity Research·Emily Oken, Matthew W Gillman
Jul 23, 2004·Nature·Patrick BatesonSonia E Sultan
Dec 22, 2004·American Journal of Human Biology : the Official Journal of the Human Biology Council·Christopher W Kuzawa, Ivy L Pike
Feb 3, 2005·Pediatrics·Lawrence M GartnerUNKNOWN American Academy of Pediatrics Section on Breastfeeding
Sep 30, 2005·Peptides·Suleyman AydinSelahattin Kumru
May 11, 2006·The American Journal of Clinical Nutrition·Lisa J MartinArdythe L Morrow
Aug 3, 2006·Maternal & Child Nutrition·Peter D GluckmanCatherine Pinal
Nov 23, 2006·Cytokine & Growth Factor Reviews·Amarjit SainiClaire E H Stewart
Jun 29, 2007·Pediatric Research·Vincenzo ZanardoMario Plebani
Sep 25, 2007·Acta Paediatrica·Yesim Ozarda Ilcol, Banu Hizli
Jul 25, 2008·Biomedical Chromatography : BMC·Suleyman AydinHikmet Geckil
Sep 6, 2008·Neuroscience and Biobehavioral Reviews·Francesca MastorciAndrea Sgoifo
Dec 24, 2008·Journal of the American Dietetic Association·Katherine Y WojcikElena T Medo
May 15, 2009·Pediatrics International : Official Journal of the Japan Pediatric Society·Bahri ErmisRahmi Ors
Dec 25, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Janna L MorrisonIsabella C McMillen
Jul 1, 2010·European Journal of Clinical Nutrition·F SavinoL Silvestro
Feb 22, 2011·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·UNKNOWN U.S. Department of Health and Human Services
Mar 3, 2011·Journal of Proteome Research·Yalin LiaoBo Lönnerdal
May 19, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·K Rooney, S E Ozanne
Nov 19, 2011·Journal of Pediatric Gastroenterology and Nutrition·Jessica G WooArdythe L Morrow
Dec 31, 2011·Nutrition Journal·Juan Antonio Costa-OrvayXavier Carbonell-Estrany

❮ Previous
Next ❯

Citations

Oct 10, 2014·Journal of Developmental Origins of Health and Disease·S A BayolG D Wadley
Jan 8, 2016·Journal of Perinatology : Official Journal of the California Perinatal Association·P G PanagosS Sen
Dec 20, 2014·Neuroscience and Biobehavioral Reviews·Matthew W HaleLuba Sominsky
Apr 5, 2013·Pediatric Obesity·B G Gibbs, R Forste
Jan 18, 2015·Women and Birth : Journal of the Australian College of Midwives·Lucia MarsegliaTeresa Arrigo
Apr 19, 2016·Scientific Reports·Katharina DingerMiguel Angel Alejandre Alcázar
Dec 3, 2015·Current Obesity Reports·Jessica G Woo, Lisa J Martin
Jul 19, 2016·Seminars in Fetal & Neonatal Medicine·Dominick J LemasElizabeth Shenkman
Sep 16, 2016·Journal of Perinatology : Official Journal of the California Perinatal Association·J M MeyersR Guillet
May 14, 2016·Annals of Human Biology·Elizabeth A Quinn, Geoff Childs
Oct 21, 2014·BoneKEy Reports·Krista CasazzaDavid A Fields
Feb 6, 2017·Clinics in Perinatology·Hans Demmelmair, Berthold Koletzko
Jun 3, 2016·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Kelley L BaumgartelYvette P Conley
Sep 13, 2016·Preventive Medicine Reports·Arsham AlamianJoseph Ikekwere
Jan 2, 2013·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Annalisa MarcuzziLorenzo Monasta
Oct 29, 2014·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Elizabeth A QuinnChristopher W Kuzawa
Feb 21, 2018·Current Opinion in Clinical Nutrition and Metabolic Care·Kamilla G EriksenKim F Michaelsen
Jun 2, 2018·PloS One·Christian HellmuthFranca F Kirchberg
Sep 12, 2018·Journal of Developmental Origins of Health and Disease·Betul KocaadamCanan Turkyilmaz
Sep 29, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Jean M DonnellyFionnuala M McAuliffe
Apr 11, 2019·The American Journal of Clinical Nutrition·Elvira IsganaitisDavid A Fields
Nov 28, 2013·Pediatric Obesity·T PriegoUNKNOWN IDEFICS Consortium
Aug 10, 2019·Journal of Developmental Origins of Health and Disease·Evangeline M DeerBernadette E Grayson
Aug 10, 2019·Nutrients·Alessandra MazzocchiFabio Mosca
Jan 18, 2020·Nutrition and Health·Gabriela E LeghiBeverly S Muhlhausler
Feb 15, 2020·American Journal of Human Biology : the Official Journal of the Human Biology Council·Duaa KuziezElizabeth A Quinn
Feb 20, 2020·Maternal & Child Nutrition·Lindsay EllsworthBrigid Gregg
Apr 16, 2020·Journal of Developmental Origins of Health and Disease·Jerad H DumoltTodd C Rideout

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.