PMID: 8583293Nov 1, 1995Paper

Relationship of interleukin-1 receptor antagonist to mucosal inflammation in inflammatory bowel disease

Journal of Pediatric Gastroenterology and Nutrition
J S HyamsD L Kreutzer

Abstract

Previous work has suggested that the interleukin-1 (IL-1) receptor antagonist, IL-1ra, may regulate mucosal inflammation in inflammatory bowel disease. The present study assessed the relationship of mucosal IL-1ra levels to histologic severity of inflammation and the related proinflammatory cytokines IL-1 beta and IL-6 in children with inflammatory bowel disease. Colonic biopsy specimens from 29 patients with ulcerative colitis, 27 with Crohn's disease, and 24 noninflammatory control subjects were assayed for IL-1ra, IL-1 beta, and IL-6 by enzyme-linked immunosorbent assay. Histologic activity was graded as none, mild, moderate, or severe. Mucosal IL-1 beta levels, but not IL-1ra levels, were significantly elevated in moderate/severely inflamed biopsies from patients with either ulcerative colitis (p < 0.01) or Crohn's disease (p < 0.001) compared with those with none/mild inflammation. The mucosal molar ratio of IL-1ra/IL-1 beta was significantly lower for moderate/severe inflammation compared with none/mild inflammation for patients with ulcerative colitis (p < 0.05) and Crohn's disease (p < 0.01). The mucosal IL-1ra/IL-1 beta ratio was similar in controls to none/mild inflamed biopsies from subjects with either ulcerative co...Continue Reading

Citations

Jul 23, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·D MeisterS Ghosh
Jul 24, 2012·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Rana Al-SadiThomas Y Ma
Feb 21, 2002·Inflammatory Bowel Diseases·Maria Oliva-Hemker, Claudio Fiocchi
Aug 1, 2006·Journal of Pediatric Gastroenterology and Nutrition·S C WongS F Ahmed
Apr 22, 2010·Journal of Cellular and Molecular Medicine·Rana Al-SadiThomas Y Ma
Nov 15, 2002·Paediatric Drugs·David A Gremse, Karen D Crissinger
Oct 3, 2006·Current Opinion in Anaesthesiology·W T McBride, S J McBride
Oct 6, 2010·Journal of Diabetes Science and Technology·Ulrike KluehDon Kreutzer

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