PMID: 2494362Jan 1, 1989Paper

Relationship of jejunostomy and urine polyamine content to refeeding and intestinal structure and function

JPEN. Journal of Parenteral and Enteral Nutrition
J S Thompson, K Laughlin

Abstract

The polyamine content of the intestinal mucosa is increased with mucosal proliferation. Our purpose was to determine if urine and jejunostomy polyamine content increases after refeeding and correlates with intestinal length and carbohydrate absorption after intestinal resection. Five patients with intestinal remnant lengths ranging from 1.5 to 8 feet after intestinal resection and jejunostomy formation were studied after refeeding of an elemental diet. Mean putrescine and spermidine levels in the jejunostomy effluent but not in the urine increased significantly after refeeding (p less than 0.05). These changes correlated with intestinal remnant length and carbohydrate absorption. Carbohydrate absorption correlated with polyamine levels in a single patient studied longitudinally. The polyamine content of intestinal fluid may serve as a marker of the status of the intestinal mucosa and may prove useful in the dietary management of individuals with the short bowel syndrome.

References

Jun 29, 1978·The New England Journal of Medicine·R C Williamson
Nov 1, 1976·The American Journal of Physiology·D V MaudsleyY Kobayashi
Jul 1, 1986·Gastroenterology·P B McIntyreJ E Lennard-Jones
Jan 1, 1987·JPEN. Journal of Parenteral and Enteral Nutrition·J S ThompsonL F Rikkers
Dec 1, 1986·Diseases of the Colon and Rectum·J S ThompsonK Laughlin
Jan 1, 1981·Differentiation; Research in Biological Diversity·O Heby
Jan 1, 1983·Critical Reviews in Clinical Laboratory Sciences·D H Russell
May 1, 1984·JPEN. Journal of Parenteral and Enteral Nutrition·P N GilchristH Harley
Nov 1, 1982·The American Journal of Physiology·A E Pegg, P P McCann

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Citations

Oct 1, 1992·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·J S ThompsonE M Quigley
Jan 1, 1991·JPEN. Journal of Parenteral and Enteral Nutrition·P P Purdum, D F Kirby

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