PMID: 6985834Jan 15, 1980Paper

Relationship of lysozyme (muramidase) to histiocytic differentiation in malignant histocytosis: an immunohistochemical study

Cancer
G MendelsohnR B Mann

Abstract

Malignant histiocytosis (MH) is a rare, usually fatal systemic disease considered to be a neoplasm of true histiocytes. Because MH may be difficult to differentiate from non-Hodgkin's lymphomas or carcinoma, we examined surgical and autopsy material from 10 patients with MH using the immunoperoxidase technique to determine if the presence of intracellular lysozyme is helpful in making this distinction. The cases of MH were divided into three groups based on the degree of cytologic atypia and the amount of phagocytic activity of the neoplastic cells: group I--minimal cytologic atypia and rare erythrophagocytosis; group II--minimal cytologic atypia with extensive erythrophagocytosis: group III--moderate to marked cytologic atypia and rare phagocytosis. Moderate to strong staining for lysozyme was observed in the neoplastic cells of group I, weak or absent staining in group II cells, and no staining in group III cells. These findings suggest the loss of detectable enzyme in poorly differentiated or dedifferentiated neoplastic histiocytes. Consideration must be given to these observations in evaluating the use of lysozyme as a possible serum or tissue aid to the diagnosis of MH.

References

Jan 1, 1976·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C R Taylor
Jul 1, 1976·The British Journal of Dermatology·J Piñol-AguadéJ Peyrí
Feb 1, 1975·Journal of Clinical Pathology·D Y Mason, C R Taylor
Feb 20, 1975·The New England Journal of Medicine·E F Osserman
Apr 15, 1976·The New England Journal of Medicine·M Klockars, O Selroos
Jan 1, 1966·Journal of Comparative Pathology·N P Markham, J G Markham
May 1, 1974·The Journal of Experimental Medicine·S GordonZ A Cohn
Feb 1, 1966·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R S BriggsS C Finch

❮ Previous
Next ❯

Citations

Jan 1, 1982·Virchows Archiv. A, Pathological Anatomy and Histology·M F Rousseau-MerckC Nezelof
Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·J HamelsJ Thiery
Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·L P RucoC D Baroni
Jul 1, 1983·The Histochemical Journal·P G Isaacson, D B Jones
Mar 1, 1988·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·M L WellmanG J Kociba
Oct 30, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·D M Goldberg, D Brown
Jan 1, 1983·Journal of the American Academy of Dermatology·M R WickR K Winkelmann
May 1, 1995·Zentralblatt für Veterinärmedizin. Reihe A·A KiparE Burkhardt
Jul 1, 1984·Acta Pathologica Japonica·A InoueH Ueno
Jan 1, 1989·Acta Pathologica Japonica·Y NakanumaK Kurashima
Dec 1, 1988·Journal of Clinical Pathology·P M KellyJ O McGee
Oct 1, 1989·Pathology, Research and Practice·K TashiroK Ohshima
Dec 1, 1988·Pathology, Research and Practice·F EckertF Gloor
Feb 1, 1987·Pathology, Research and Practice·L SchugerE Rosenmann
Oct 1, 1989·British Journal of Haematology·C A HansonG Frizzera
Jun 1, 1985·The Journal of Pathology·C E du Boulay
Jul 1, 1983·Histopathology·J J Butler
Sep 1, 1985·Histopathology·P G Isaacson
Jan 1, 1989·Critical Reviews in Oncology/hematology·B FaliniM F Martelli
Feb 12, 2013·Research in Veterinary Science·O PacielloA Perillo
Oct 15, 1985·Cancer·H J Ree, M E Kadin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Cell Wall Structure (ASM)

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Bacterial Cell Wall Structure

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.