PMID: 3885219Mar 1, 1985Paper

Relationship of M protein genes in group A streptococci

Proceedings of the National Academy of Sciences of the United States of America
J R ScottV A Fischetti

Abstract

The M protein of group A streptococci is considered one of the primary virulence determinants of this organism because it prevents phagocytosis. All of the 56 different M protein types of group A streptococci tested contain a DNA region that hybridizes with a labeled probe consisting of DNA encoding the type 6 M protein (emm6 gene). In addition, 2 of 3 functionally M- group A strains (strains that are successfully phagocytized) also contain this gene, but this DNA is not present in 1 M- strain. Of the other streptococcal groups, only groups C and G, which are closely related to group A, contain DNA that hybridizes with emm6. None of the non-streptococcal Gram-positive bacteria tested contains emm6-related DNA. In the strain from which emm6 was cloned, there appears to be only a single copy of this gene.

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Citations

Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M G Caparon, J R Scott
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D E HrubyV A Fischetti
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·K F JonesV A Fischetti
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R D HorstmannV A Fischetti
Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·D W DunneK A Joiner
Jun 1, 1985·The Journal of Experimental Medicine·V A FischettiJ R Scott
Nov 1, 1986·The Journal of Experimental Medicine·J R ScottV A Fischetti
Apr 6, 2013·The Journal of Antimicrobial Chemotherapy·Yang ShenDaniel C Nelson
Nov 1, 1991·The British Journal of Dermatology·J McFaddenL Fry
Mar 1, 1995·Molecular Microbiology·J Perez-CasalJ R Scott
Jul 25, 2000·Clinical Microbiology Reviews·M W Cunningham
Mar 27, 2002·Journal of Bacteriology·Timothy C Barnett, June R Scott
Nov 22, 2011·Emerging Infectious Diseases·Patrick R SheaJames M Musser
Apr 4, 2012·Emerging Infectious Diseases·Nahuel FittipaldiJames M Musser
Mar 1, 1988·Zentralblatt Für Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology·O KühnemundW Köhler
Nov 17, 2007·Molecular Microbiology·Samantha A Roberts, June R Scott
Mar 1, 1992·Microbial Pathogenesis·H S CourtneyD L Hasty
Mar 22, 2014·Journal of Clinical Microbiology·Taryn B T AtheyNahuel Fittipaldi
Dec 1, 1991·Molecular Microbiology·K F JonesV A Fischetti
May 22, 2018·Open Forum Infectious Diseases·Sarah TeateroNahuel Fittipaldi
Mar 1, 2013·Emerging Microbes & Infections·Nahuel FittipaldiJames M Musser
May 1, 1991·Infection and Immunity·M G CaparonJ R Scott
Jul 1, 1989·Clinical Microbiology Reviews·V A Fischetti
Mar 1, 1990·Infection and Immunity·J B DaleD Schifferli
Sep 1, 1992·Infection and Immunity·L A Barnett, M W Cunningham
Mar 1, 1987·Infection and Immunity·A L BisnoW R McCabe

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