PMID: 3885219Mar 1, 1985Paper

Relationship of M protein genes in group A streptococci

Proceedings of the National Academy of Sciences of the United States of America
J R ScottV A Fischetti


The M protein of group A streptococci is considered one of the primary virulence determinants of this organism because it prevents phagocytosis. All of the 56 different M protein types of group A streptococci tested contain a DNA region that hybridizes with a labeled probe consisting of DNA encoding the type 6 M protein (emm6 gene). In addition, 2 of 3 functionally M- group A strains (strains that are successfully phagocytized) also contain this gene, but this DNA is not present in 1 M- strain. Of the other streptococcal groups, only groups C and G, which are closely related to group A, contain DNA that hybridizes with emm6. None of the non-streptococcal Gram-positive bacteria tested contains emm6-related DNA. In the strain from which emm6 was cloned, there appears to be only a single copy of this gene.


Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
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Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M G Caparon, J R Scott
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