Relationship of maternal autoimmune response to clinical manifestations in children with congenital complete heart block

Acta Paediatrica
M EronenH Julkunen

Abstract

To study the autoimmune response in mothers of children with congenital heart block (CHB) diagnosed at different ages and with different clinical manifestations. Clinical data and sera for the determination of immunological tests were available from 104 mothers of 113 children born between 1950 and 2000 and diagnosed with CHB before the age of 16 y. Prenatal diagnosis was performed in 74 (65%) children of 65 mothers, and 39 (35%) children had postnatal diagnosis of CHB. Maternal antibodies to 52 kd and 60 kd SS-A, and to 48 kd SS-B were determined by time-resolved fluoroimmunoassay (TR-FIA) and to antinuclear antibodies (ANA) by immunoflurescense (IF). Out of the 65 mothers of children with in utero diagnosed CHB, 88% had antibodies to 52 kd SS-A and 83% had ANA. Antibodies to 60 kd SS-A and 48 kd SS-B were less frequently present, in 48% and in 54% of the mothers, respectively. Seven (11%) of the mothers were negative by all immunoassays. Of the 13 mothers of children with in-infancy diagnosed CHB, one mother had high-titer ANA. After 1 y of age, CHB was diagnosed in 26 children; at 1 to 6 y in 16 and after 7 y in 10 children; 1/16 and 1/10 patients had positive antibodies. In all twin pregnancies (n = 4) and in all families w...Continue Reading

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Citations

May 2, 2012·Arthritis Research & Therapy·Aurélie Ambrosi, Marie Wahren-Herlenius
Jan 15, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Mustafa Ali AkinTamer Gunes
Aug 11, 2010·Scandinavian Journal of Immunology·S Salomonsson, L Strandberg
Aug 6, 2011·Scandinavian Journal of Immunology·S SalomonssonM Wahren-Herlenius
Oct 30, 2013·Acta Paediatrica·Gunnar BergmanMarie Wahren-Herlenius
Jan 18, 2014·Experimental Cell Research·Aurélie AmbrosiMarie Wahren-Herlenius
Jan 15, 2016·Lupus·P Brito-ZerónM A Khamashta
Mar 4, 2005·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Masahiro Iwamoto
Mar 25, 2015·Nature Reviews. Rheumatology·Pilar Brito-ZerónMunther A Khamashta
Sep 29, 2017·Rheumatology·Sven-Erik SonessonMarie Wahren-Herlenius
Jan 4, 2022·Lupus·Sanitra AnuwutnavinNalat Sompagdee

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