PMID: 7353201Feb 1, 1980Paper

Relationship of metastatic medullary thyroid carcinoma to calcitonin content of pheochromocytomas: an immunohistochemical study

Cancer
G MendelsohnJ C Eggleston

Abstract

Immunoperoxidase studies have been utilized to investigate further the previously reported presence of immunoassayable calcitonin in pheochromocytoma tissue from some patients with MEN II syndromes. We have been able to demonstrate calcitonin in pheochromocytoma tissue only in two patients with MEN II syndromes in whom the pheochromocytomas contained metastatic medullary thyroid carcinoma. In both cases, the calcitonin was present only in the medullary carcinoma. We have not been able to demonstrate immunoreactive calcitonin in normal adrenal glands or in pheochromocytomas of other patients with and without MEN syndromes. Adrenal medullary cells and thyroid C cells are both of neural crest origin and both possess APUD characteristics. The presence of calcitonin in medullary thyroid carcinoma cells and not in pheochromocytes has important implications with regard to cellular differentiation and peptide hormone production.

References

Mar 1, 1978·Human Pathology·R A Wilson, M L Ibanez
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May 1, 1969·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A G Pearse
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Sep 1, 1968·Cancer·L V CampbellA L Watne

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Citations

Jan 11, 1992·Human Pathology·M M SteinhoffK DeSchryver-Kecskemeti
Apr 1, 1985·European Journal of Cancer & Clinical Oncology·F Engbaek
Jan 1, 1984·Critical Reviews in Oncology/hematology·C J LipsC B Lamers

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