Relationship of Microbial Profile With Airway Immune Response in Eosinophilic or Neutrophilic Inflammation of Asthmatics

Allergy, Asthma & Immunology Research
Ji Hye SonChoon-Sik Park

Abstract

Different characteristics of airway microbiome in asthmatics may lead to differential immune responses, which in turn cause eosinophilic or neutrophilic airway inflammation. However, the relationships among these factors have yet to be fully elucidated. Microbes in induced sputum samples were subjected to sequence analysis of 16S rRNA. Airway inflammatory phenotypes were defined as neutrophils (>60%) and eosinophils (>3%), and inflammation endotypes were defined by levels of T helper (Th) 1 (interferon-γ), Th2 (interleukin [IL]-5 and IL-13), Th-17 (IL-17), and innate Th2 (IL-25, IL-33, and thymic stromal lymphopoietin) cytokines, inflammasomes (IL-1β), epithelial activation markers (granulocyte-macrophage colony-stimulating factor and IL-8), and Inflammation (IL-6 and tumor necrosis factor-α) cytokines in sputum supernatants was assessed by enzyme-linked immunosorbent assay. The numbers of operational taxonomic units were significantly higher in the mixed (n = 21) and neutrophilic (n = 23) inflammation groups than in the paucigranulocytic inflammation group (n = 19; p < 0.05). At the species level, Granulicatella adiacens, Streptococcus parasanguinis, Streptococcus pneumoniae, Veillonella rogosae, Haemophilus parainfluenzae, an...Continue Reading

References

Jan 1, 1985·Annual Review of Microbiology·E A DelwicheM L Tortorello
Sep 1, 1994·American Journal of Respiratory and Critical Care Medicine·W D ClappD A Schwartz
Oct 1, 1996·The European Respiratory Journal·W G KuschnerP D Blanc
Dec 13, 2000·Microbes and Infection·B Rosan, R J Lamont
Aug 10, 2001·The Journal of Allergy and Clinical Immunology·C E Reed, D K Milton
Sep 11, 2001·American Journal of Respiratory and Critical Care Medicine·A ten BrinkeE H Bel
Dec 18, 2003·Cellular Microbiology·Isabel Veiga-MaltaPaula Ferreira
Mar 6, 2004·Science·Volker BrinkmannArturo Zychlinsky
Jan 21, 2006·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jodie L SimpsonPeter G Gibson
Feb 25, 2006·Nature Reviews. Immunology·Carl Nathan
May 19, 2006·The European Respiratory Journal·I D PavordA J Wardlaw
Jul 13, 2007·Journal of Clinical Microbiology·J Michael Janda, Sharon L Abbott
Oct 24, 2007·The Journal of Allergy and Clinical Immunology·Robert P SchleimerPedro C Avila
Jan 2, 2008·The European Respiratory Journal·E D BatemanH J Zar
Apr 24, 2009·Proceedings of the American Thoracic Society·John V Fahy
Jul 23, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G M GauvreauJ A Denburg
Nov 20, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Takako Miki-HosokawaToshinori Nakayama
Jan 7, 2010·PloS One·Markus HiltyWilliam O C Cookson
Nov 16, 2010·Pulmonary Pharmacology & Therapeutics·C E Brightling
Apr 8, 2011·The ISME Journal·Daniel Pr HerlemannAnders F Andersson
Nov 2, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jae-Sung ChoiChoon Sik Park
Dec 8, 2011·Journal of Molecular Cell Biology·Anne-Gaelle BesnardBernhard Ryffel
Jul 4, 2012·Current Opinion in Pharmacology·Emily Hams, Padraic G Fallon
Sep 8, 2012·Future Microbiology·Yu-Ching SuKristian Riesbeck
Dec 26, 2012·The Journal of Allergy and Clinical Immunology·Pradeep Reddy MarriFernando D Martinez
Feb 23, 2013·Lancet·Trevor T HanselPeter J Openshaw
Mar 23, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Y-S KimY-K Kim
Apr 20, 2013·Trends in Microbiology·Geraint B RogersKenneth D Bruce
Sep 13, 2013·American Journal of Respiratory and Critical Care Medicine·Elena GolevaDonald Y M Leung
Oct 19, 2013·The European Respiratory Journal·Jodie L SimpsonPeter G Gibson
Dec 10, 2015·The European Respiratory Journal·Jodie L SimpsonPeter G Gibson
May 10, 2017·The Journal of Allergy and Clinical Immunology·Steven L TaylorGeraint B Rogers
Jul 12, 2017·Allergology International : Official Journal of the Japanese Society of Allergology·So-Ichiro Hirata, Jun Kunisawa
Jun 22, 2018·The Journal of Allergy and Clinical Immunology·Omar Tliba, Reynold A Panettieri
Mar 27, 2019·International Journal of Medical Sciences·Zhiqiang PangFang Wang

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Citations

Jun 5, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Bingqing ShiPeng Gao
Mar 7, 2020·Allergy, Asthma & Immunology Research·Young Joo Cho
Mar 19, 2021·Allergy, Asthma & Immunology Research·Na LiuXiang Ping Yang
Sep 7, 2021·Frontiers in Immunology·Sharon Van NevelOlga Krysko

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Methods Mentioned

BETA
PCR
ELISA

Software Mentioned

SPSS

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