Relationship of muscle function to circulating myostatin, follistatin and GDF11 in older women and men

BMC Geriatrics
Elizaveta FifeTomasz Kostka

Abstract

Myostatin, its inhibitor follistatin, and growth/differentiation factor 11 (GDF11) have been proposed as factors that could potentially modify biological aging. The study aimed to test whether there is a relationship between these plasma circulating proteins and muscle strength, power and optimal shortening velocity (υopt) of older adults. The cross-sectional study included 56 women and 45 men aged 60 years and older. Every participant underwent examination which included anthropometric and bioimpedance analysis measurements, functional and cognitive performance tests, muscle strength of upper and lower extremities, muscle power testing with two different methods and blood analyses. Women had higher plasma levels of myostatin and GDF11 than men. Men had higher plasma level of follistatin than women. In women, plasma level of myostatin was negatively correlated with left handgrip strength and υopt. Follistatin was negatively correlated with maximum power output (Pmax), power relative to kg of body mass (Pmax∙kg- 1) (friction-loaded cycle ergometer) and power at 70% of the 1-repetition maximum (1RM) strength value (P70%) of leg press (Keiser pneumatic resistance training equipment), and positively correlated with the Timed Up & G...Continue Reading

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Citations

Feb 16, 2020·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Tatsuki IchikawaKazuhiko Nakao
Dec 19, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Yunan ZhouNaomi Clyne
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Nov 5, 2019·Frontiers in Oncology·Arturo Simoni-NievesMaría Concepción Gutiérrez-Ruiz
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Feb 9, 2021·American Journal of Physiology. Endocrinology and Metabolism·Hiroshi KumagaiSu-Jeong Kim
Jul 25, 2021·International Journal of Environmental Research and Public Health·Soo Jeong ChoiWon Suk An
Mar 15, 2019·Gerontology·Michaël R LaurentEvelien Gielen

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