Relationship of Neutrophil-to-Lymphocyte Ratio with Aortic Stiffness in Type 1 Diabetes Mellitus

Canadian Journal of Diabetes
Hüseyin AyhanEngin Bozkurt

Abstract

Emerging evidence suggests that the neutrophil-to-lymphocyte ratio (NLR) may be a useful marker of inflammation and aortic stiffness. Markers of inflammation and aortic stiffness are both indicators of cardiovascular events. We, therefore, investigated whether the NLR is associated with aortic stiffness in patients with type 1 diabetes mellitus. We examined the relationship of the NLR to aortic stiffness in 76 people with type 1 diabetes and 36 healthy controls. The NLRs in the group with type 1 diabetes were higher than in the controls (2.33±0.95 vs. 1.80±0.68, respectively; p=0.003). Aortic strain and aortic distensibility, the parameters of aortic stiffness, measured noninvasively by the help of echocardiography, were significantly decreased in the patient group compared to controls (8.0%±1.5% vs. 13.1%±3.3 %; p<0.001 and 3.6±1.1 cm(2).dyn(-1).10(-3) vs. 6.0±2.1 cm(2).dyn(-1).10(-3); p<0.001, respectively). There were negative correlations between NLR and distensibility (r: -0.40; p<0.001) and strain (r: -0.57; p<0.001) in patients with type 1 diabetes. We have demonstrated that there is a significant negative correlation between the NLR and markers of aortic stiffness in patients with type 1 diabetes, indicating a potential...Continue Reading

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Citations

Feb 25, 2018·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Mario Fritsch NevesWille Oigman
Mar 3, 2020·American Journal of Hypertension·Olga BerilloErnesto L Schiffrin
Sep 16, 2017·Frontiers in Immunology·Ioana MozosAtanas G Atanasov
Jun 12, 2017·The Kaohsiung Journal of Medical Sciences·Narin Nasıroglu ImgaSerdar Guler
May 27, 2017·Current Medicinal Chemistry·Tarik SmaniAbdelkrim Hmadcha
Jul 1, 2021·The Journal of International Medical Research·Maki KomiyamaKoji Hasegawa

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