Relationship of partially purified factor concentrates to immune tests and AIDS. The Hemophilia-AIDS. Collaborative Study Group

American Journal of Hematology
J JasonB L Evatt

Abstract

We evaluated those members of a cohort of 203 hemophilic men providing all necessary information at their 1984 and 1985 evaluations, to determine whether non-heated or less than 80 degrees C dry heat-treated partially purified factor products were associated with 1) the development of AIDS in human immunodeficiency virus (HIV)-infected persons or 2) abnormal immune test results in participants seroconverting or remaining HIV seronegative. We found no relationship between type of factor (VIII vs. IX) (n = 162), frequency of usage (greater than or equal to once a week vs. less than once a week) (n = 141) or yearly doses of non-heated or dry heat-treated partially purified factor (n = 118) and the development of AIDS. Seroconverting participants using partially purified factor products greater than or equal to once a week in 1984 had lower T-helper cell numbers in 1985 than those receiving factor less frequently (median 515 vs. 772/mm3, n = 9), as did those using factor greater than or equal to once a week in 1985 (median 515 vs. 726/mm3, n = 10). A similar relation was seen between 1984 frequency and 1985 T-helper cell numbers of seronegative participants (median 741 vs. 1037/mm3, n = 31). The yearly dose of heat-treated products...Continue Reading

References

Feb 1, 1988·Journal of Interferon Research·A RuffaultB Fauconnier
Apr 19, 1985·JAMA : the Journal of the American Medical Association·M E EysterW A Blattner
Jun 17, 1988·JAMA : the Journal of the American Medical Association·M CattaneoP M Mannucci
Oct 13, 1988·The New England Journal of Medicine·L M AledortR A Lipton
Feb 22, 1985·JAMA : the Journal of the American Medical Association·J JasonB Evatt

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Citations

Jan 1, 1992·Pharmacology & Therapeutics·P H Duesberg
Apr 1, 1996·Haemophilia : the Official Journal of the World Federation of Hemophilia·D P AllersmaE Briët
Aug 1, 1992·Journal of Clinical Laser Medicine & Surgery·A Santos-Dias

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