PMID: 9191882Jul 1, 1997Paper

Relationship of plasma HIV-RNA levels and levels of TNF-alpha and immune activation products in HIV infection

Clinical Immunology and Immunopathology
J F Salazar-GonzalezJ L Fahey

Abstract

The goal of this study was to determine the relationship between plasma human immunodeficiency virus (HIV) load and cytokine expression. HIV-RNA plasma levels were determined in 34 HIV-seropositive (HIV+) asymptomatic subjects [range: 0.5 to 211 kiloequivalents (kEq)/ml HIV-RNAJ, by a modified branched-DNA (bDNA) assay. Plasma HIV-RNA levels were positively correlated with increased plasma levels of TNF-alpha, soluble TNF receptor type II, soluble IL-2 receptor, beta 2-microglobulin, and neopterin, but not with plasma IL-6 levels. In contrast, increased viral load and diminished CD4 counts correlated weakly. TNF-alpha mRNA levels, as determined by bDNA technology, were not significantly increased in peripheral blood mononuclear cells (PBMC) isolated from HIV-infected subjects, compared to HIV-seronegative (HIV-) subjects, and were not correlated with plasma levels of HIV-RNA, cytokines, or activation markers. These results are consistent with the hypothesis that a self-reinforcing mechanism exists between TNF-alpha production and generalized immune activation on one hand with HIV replication on the other.

References

Apr 15, 1991·Annals of Internal Medicine·A S FauciG Pantaleo
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·T M FolksA S Fauci
Apr 15, 1995·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·C PachlB Irvine
Apr 15, 1995·Annals of Internal Medicine·J W MellorsP Gupta
Jan 1, 1996·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·A Marfaing-KokaJ Wijdenes
Mar 1, 1996·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·J D KlausnerG Kaplan

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Citations

Nov 30, 2000·Current Infectious Disease Reports·M Holodniy
May 3, 2005·Journal of Theoretical Biology·Jacob P Couturier, Robert S Root-Bernstein
Oct 5, 2010·Journal of Proteome Research·Elena Vendrame, Otoniel Martínez-Maza
Jul 13, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Monica GandhiRuth M Greenblatt
Mar 1, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Donna MildvanJonathan Kagan
Oct 22, 2008·AIDS Research and Human Retroviruses·P MorlatUNKNOWN ANRS CO8 Aproco-Copilote Study Group
May 17, 2007·International Journal of Clinical Practice·L Waters, M Nelson
Mar 18, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·S PlaegerJ L Fahey
May 19, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·M SavèsJ Beylot
Sep 6, 2001·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·J Salas-Salvadó, P García-Lorda
Apr 3, 1999·Viral Immunology·J N Breuer-McHamM Duvic
Feb 22, 2011·European Journal of Immunology·Regina C MillerRoberto F Speck
Apr 11, 2013·Journal of Leukocyte Biology·Emma TippettSuzanne M Crowe
Jan 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K V KhannaR B Markham

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