Abstract
Systemic lupus erythematosus (SLE) is associated with premature atherosclerosis. Recent studies indicated that the concentrations of circulating interleukin (IL)-18, a novel proinflammatory T helper-1 cytokine, in SLE patients were significantly higher than those in healthy control subjects. The objective of this study was to examine the relationship between IL-18 and cardiovascular risk factors in patients with SLE. Both traditional and non-traditional cardiovascular risk factors including body mass index (BMI), systolic blood pressure, diastolic blood pressure (DBP), fasting insulin and glucose, plasma lipid profile, plasma homocysteine, thiobarbituric acid-reactive substances, titres of autoantibodies against oxidized low-density lipoprotein, and brachial-ankle pulse wave velocity (baPWV) were determined in a total of 72 female SLE patients. All patients were further classified into subgroups based on tertiles of plasma IL-18 concentrations. Plasma concentrations of IL-18 were significantly higher in SLE patients than age-matched healthy controls. SLE patients with IL-18 concentration in the top tertile compared with the bottom tertile had significantly higher plasma levels of insulin, triglyceride, homocysteine and values o...Continue Reading
Citations
Sep 24, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Rafael Fernandes ZaninAna Maria Oliveira Battastini
May 11, 2013·Eye·K TürkyılmazM Durmus
Feb 24, 2009·Nature Clinical Practice. Cardiovascular Medicine·Simon W Rabkin
Sep 9, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tomasz PorazkoMarian Klinger
Apr 9, 2010·International Journal of Rheumatic Diseases·Ismail SariNurullah Akkoc
Sep 14, 2010·Journal of Periodontology·Rosamma JosephM G Joseraj
Jan 10, 2009·Fertility and Sterility·Cemil KayaHakan Satiroglu
Jul 1, 2007·Expert Review of Clinical Immunology·Elena Bartoloni BocciRoberto Gerli
Mar 1, 2009·Expert Opinion on Medical Diagnostics·Irene Meester, Juan Manuel Solis-Soto
Feb 23, 2008·Current Eye Research·Tongabay CumurcuHuseyin Yardim
Jun 13, 2015·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Barkath Nisha Hyderali, Kanchana Mala
Oct 20, 2009·Atherosclerosis·Marius TrøseidHarald Arnesen
Jul 24, 2007·Autoimmunity Reviews·Pietro Enea LazzeriniFranco Laghi Pasini
Feb 28, 2014·Cardiovascular Therapeutics·Balazs Debreceni, Laszlo Debreceni
Jan 16, 2010·American Journal of Hypertension·Charalambos VlachopoulosChristodoulos Stefanadis
Sep 14, 2014·Lupus·J M SabioJ Jiménez-Alonso
Mar 3, 2012·Clinical and Experimental Reproductive Medicine·Chan Woo ParkKwang Moon Yang
Oct 27, 2009·Journal of Glaucoma·Nurşen YükselYusuf Cağlar
Nov 2, 2019·Bioscience Reports·Xiran LinZhiqi Song
Jan 14, 2020·Chinese Medical Journal·Yue-Miao ZhangHong Zhang
May 29, 2020·Clinical and Translational Science·Roberta Natália CestariVera Lucia Lanchote
Oct 5, 2010·Arthritis Care & Research·Young Hee RhoC Michael Stein
Dec 17, 2011·The Journal of Rheumatology·Carol M GrecoSusan Manzi
Mar 28, 2008·Expert Review of Molecular Diagnostics·Chang-Hee Suh, Hyoun-Ah Kim
Dec 13, 2018·Clinical Rheumatology·Paola A Zeña-HuancasManuel F Ugarte-Gil
Nov 11, 2018·BMC Medical Genetics·Alicja E GrzegorzewskaPaweł P Jagodziński
Feb 25, 2020·Clinical Rheumatology·Napoleon Bellua SamDong-Qing Ye
Feb 27, 2021·Scientific Reports·Mengmeng XiangJinhua Xu