Relationship of plasma oxytocin levels to baseline symptoms and symptom changes during three weeks of daily oxytocin administration in people with schizophrenia

Schizophrenia Research
Mary R LeeDeanna L Kelly

Abstract

Several clinical studies have found an inverse relationship between clinical symptoms and peripheral oxytocin (OT) levels in people with schizophrenia. As oxytocin is a putative treatment for schizophrenia, the effect of repeated dosing of OT on OT levels, clinical symptoms and the relationship between the two is of interest. In a, randomized, double blind, parallel group 3 week study (N=28) with daily administration of intranasal OT (20 IU twice daily) or placebo (PBO), we examined the effect of OT administration on the correlation between the change in peripheral OT levels and change in clinical symptoms in patients with schizophrenia. At baseline, there were no significant treatment group differences in OT levels. There were no significant associations between baseline OT levels and any symptom measures. After 3 weeks of OT/PBO dosing, there was no significant difference in the magnitude of change in OT levels between the two treatment groups. Correlations between changes in peripheral OT levels and changes in the BPRS total and negative symptom scores were not different between treatment groups. Larger studies are needed to examine the effect of exogenous OT on peripheral OT levels and the relationship between the latter an...Continue Reading

Associated Clinical Trials

Oct 4, 2012·Giovanni de Girolamo, M.D.

References

Jan 1, 1984·European Archives of Psychiatry and Neurological Sciences·P LinkowskiJ J Legros
Oct 29, 2005·Schizophrenia Bulletin·Jack J Blanchard, Alex S Cohen
Dec 17, 2008·Trends in Cognitive Sciences·David H Skuse, Louise Gallagher
Jul 10, 2010·Biological Psychiatry·David FeifelAllison Hadley
Oct 16, 2010·Schizophrenia Research·Leah H RubinPauline M Maki
Jun 21, 2011·Schizophrenia Research·Leah H RubinPauline M Maki
Feb 13, 2015·Schizophrenia Research·Gregory P StraussRobert W Buchanan

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Citations

Sep 7, 2016·Frontiers in Human Neuroscience·Martin DebbanéBenjamin K Brent
Sep 17, 2016·Drug Development Research·Nadja P MaricCedo Miljevic
Nov 7, 2017·Postgraduate Medicine·Miho OtaHiroshi Kunugi
Jan 19, 2019·Pituitary·Yuval EisenbergBrian T Layden
Mar 31, 2021·Journal of Clinical Psychopharmacology·Robert W BuchananEric Granholm

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