Relationship of "prodromal" symptoms with severity and type of psychopathology in the active phase of schizophrenia

Comprehensive Psychiatry
George MoukasS Beratis

Abstract

Both retrospective and prospective studies have identified a broad spectrum of "prodromal" symptoms, but their relationship to those of frank psychosis remains largely unexplored. In 73 successive hospitalized patients with schizophrenia in the first or second psychotic episode and with duration of illness 3 years or less from the onset of psychosis, Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision, Axis I diagnoses were made. In addition, within the first 5 days from the psychotic episode's onset, symptom severity was assessed with the Positive and Negative Syndrome Scale (PANSS). Stepwise regression analyses showed that 8 prodromal symptoms carried an increased risk for high total PANSS and the components of the PANSS scores, independently of sex; 1 symptom was associated with mild psychopathology. However, the categories of negative- and positive-disorganization prodromal symptoms were not associated with the corresponding PANSS components. Similar findings were observed in the nonparanoid patients, whereas in the paranoid, only 2 nonspecific symptoms were associated with high PANSS psychopathology. In addition, there were significant associations between number of prodromal symptoms and t...Continue Reading

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Citations

Feb 22, 2012·Comprehensive Psychiatry·James WilcoxMing Tsuang
Dec 28, 2010·Comprehensive Psychiatry·Ioannis AndriopoulosStavroula Beratis
Nov 9, 2017·Early Intervention in Psychiatry·Ana BarajasSusana Ochoa
Jul 18, 2018·Journal of Psychiatric Practice·Zachary D ZuschlagMark Hamner
Mar 13, 2019·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Osman KayapinarAdnan Kaya

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