PMID: 6108222Nov 1, 1980Paper

Relationship of propranolol pharmacokinetics to antihypertensive effect and beta-adrenergic blockade in the treatment of hypertension

European Journal of Clinical Pharmacology
R T KredietL Offerhaus

Abstract

The pharmacokinetics of propranolol in 16 hypertensive patients was compared after the first oral dose of 80 mg and during chronic treatment with 80 mg bd. The degree of beta-adrenergic blockade was estimated by the reduction in maximal exercise heart rate. No significant change in plasma half-life occurred and there was no correlation between the mean steady-state propranolol concentration and beta-adrenergic blockade or antihypertensive effect. A linear relationship was observed between the decrease in blood pressure and the reduction in heart rate during maximal exercise. Therefore, the antihypertensive effect of propranolol can be explained by it peripheral beta-adrenergic blocking properties.

References

Jul 3, 1976·British Medical Journal·C DavidsonS H Taylor
Mar 11, 1977·European Journal of Clinical Pharmacology·A LehtonenT Kleimola
Aug 1, 1976·Clinical Pharmacology and Therapeutics·D G McDevittD G Shand
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Dec 1, 1976·British Journal of Clinical Pharmacology·L Offerhaus, J R van der Vecht

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Citations

Apr 1, 1986·European Journal of Drug Metabolism and Pharmacokinetics·S SäköM Anttila
Jan 1, 1984·Comprehensive Psychiatry·B H TearnanP Keefe
May 1, 1987·Journal of Clinical Pharmacology·D C GargD J Weidler
Jan 1, 1982·Springer Seminars in Immunopathology·S W ManleyD D Adams
Apr 14, 2017·CNS Drugs·Peer Tfelt-HansenJacob Tfelt-Hansen

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