Relationship of quadriceps muscle power and optimal shortening velocity with angiotensin-converting enzyme activity in older women

Clinical Interventions in Aging
Joanna KostkaTomasz Kostka

Abstract

The goal of this study was to assess whether angiotensin-converting enzyme (ACE) activity is related to muscle function (strength, power and velocity), as well as to assess if ACE inhibitors (ACEIs) and other angiotensin system blocking medications (ASBMs) influence muscle performance in elderly women. Ninety-five community-dwelling elderly women took part in this study. Anthropometric data, blood ACE activity analysis, maximum power (Pmax) and optimal shortening velocity (υopt) of the knee extensor muscles, handgrip strength, physical activity (PA) and functional performance were measured. Women taking ACEI were on average almost 2 years older than the women who did not take ACEI. They took more medicines and were also characterized by significantly lower level of ACE, but they did not differ in terms of PA level, results of functional performance and parameters characterizing muscle functions. No correlations of ACE activity with Pmax and handgrip strength, as well as with PA or functional performance were found. Higher ACE activity was connected with lower υopt for women who did not take any ASBMs (rho =-0.37; p=0.01). Serum ACE activity was not associated with muscle strength, power and functional performance in both ASBM u...Continue Reading

Citations

Oct 19, 2019·International Journal of Molecular Sciences·Annunziatina LaurinoLaura Sartiani
Jan 5, 2021·Aging Clinical and Experimental Research·Timur EkizLevent Özçakar

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