Relationship of quality of life scores with baseline characteristics and outcomes in the African-American heart failure trial

Journal of Cardiac Failure
Peter CarsonInder S Anand

Abstract

To characterize the quality of life (QOL) in the African-American Heart Failure Trial (A-HeFT) for factors associated with baseline score, relation of score to prognosis, and response to therapy with a fixed-dose combination of isosorbide dinitrate/hydralazine (FDC I/H). Limited data exist on QOL scores in African-American heart failure patients or on the prognostic value of theses scores in any population. Finally, the effect of FDC I/H on QOL scores, particularly in A-HeFT, is not known. A-HeFT randomized 1050 African-American patients with New York Heart Association (NYHA) Class III-IV heart failure and systolic dysfunction. QOL measurements using Minnesota Living with Heart Failure Questionnaire (MLHFQ) were done at baseline and 3-month intervals. At baseline, worse MLHFQ scores were associated with younger age, female sex, greater body mass index, nonischemic etiology, high heart rate and NYHA Class, low systolic blood pressure, and chronic obstructive pulmonary disease. Both baseline and change in MLHFQ score were associated with a higher risk for combined all-cause mortality or heart failure hospitalization (baseline P < .0001, change at 3 months P=.001, and at 6 months P=.0008), but not mortality. Treatment with FDC I/H...Continue Reading

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Citations

May 21, 2011·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Sofia V ChatzikyriakouStavros Konstantinides
May 3, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Naoko KatoRyozo Nagai
Apr 30, 2013·Circulation. Heart Failure·Alanna M ChamberlainVéronique L Roger
Apr 20, 2012·Revista Española De Cardiología·Luiz E RittRenato D Lopes
Dec 14, 2011·European Journal of Clinical Investigation·Max PlischkeMartin Hülsmann
Sep 21, 2011·International Journal of Cardiology·Jodie InglesChristopher Semsarian
May 23, 2014·The American Journal of Cardiology·Keith Copelin FerdinandChristopher Leggett
Nov 21, 2015·European Journal of Cardiovascular Nursing : Journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology·Tzu-Chieh WangAi-Fu Chiou
May 30, 2014·Journal of the American Heart Association·Alanna M ChamberlainVéronique L Roger
Jan 22, 2015·Circulation. Heart Failure·Nancy M AlbertUNKNOWN American Heart Association Complex Cardiovascular Patient and Family Care Committee of the Council on Cardiovascular and Str
Feb 28, 2020·The Cochrane Database of Systematic Reviews·Meaghan LunneyPietro Ravani
Nov 21, 2019·Heart Failure Reviews·Mandana MoradiMohammad Raeisi
Jul 31, 2010·European Journal of Heart Failure·Fátima das Dores CruzEdimar Alcides Bocchi
Sep 1, 2018·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Henrique Silveira CostaManoel Otávio da Costa Rocha
Oct 9, 2020·Health and Quality of Life Outcomes·Josep Comín-ColetSilvia Jiménez Merino

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