May 16, 2009

Relationship of retinal vascular caliber with retinal nerve fiber layer thickness: the singapore malay eye study

Investigative Ophthalmology & Visual Science
Yingfeng ZhengTien Y Wong


To describe the relationship of retinal arteriolar and venular caliber with retinal nerve fiber layer (RNFL) thickness. A population-based, cross-sectional study of Malay persons aged 40 to 80 years residing in Singapore was conducted from 2004 to 2006. Retinal arteriolar and venular calibers were measured with a computer-based technique according to a validated, standardized protocol. RNFL was assessed with retinal tomography. There were 2706 persons with gradable retinal photographs and HRT images of acceptable quality available for analysis. In linear regression models that adjusted for age, sex, diabetes, body mass index, intraocular pressure, and other factors, each standard deviation decrease in arteriolar and venular caliber was associated with a 5.81- and 8.37-microm decrease, respectively, in mean global RNFL thickness (both P < 0.001). These associations remained similar after persons with glaucoma were excluded. In persons with glaucoma, retinal venular caliber was independently associated with the temporal and temporal-to-inferior region of mean RNFL thickness in multivariate analysis; each SD decrease in retinal venular diameter was associated with an 8.54-microm decrease in the temporal region (P = 0.022), and a 3...Continue Reading

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Mentioned in this Paper

Prevalence Studies
Cerebellar Mossy Fibers
Temporal Region
Nerve Fibers
X-Ray Computed Tomography
Intraocular Pressure Test
Retinal Vascular
Structure of Arteriole

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