PMID: 2504068Jul 1, 1989Paper

Relationship of route of infection to susceptibility and immune response of inbred mice to Y strain Trypanosoma cruzi

The American Journal of Tropical Medicine and Hygiene
D J MurfinR E Kuhn

Abstract

C3HeB/FeJ (C3H) mice infected ip with 10(6), 5 x 10(5), and 10(5) blood-form trypomastigotes (BFTs) of the Y strain of Trypanosoma cruzi were more resistant than C57B1/6 (B6) mice infected in the same manner. This pattern of susceptibility is opposite that reported for other stocks of this parasite. In a second experiment, C3H and B6 mice were infected ip or sc with 2 x 10(6), 10(6), 5 x 10(5), 10(5), or 10(3) Y strain BFTs. C3H mice infected ip with the 3 highest doses were again more resistant than the B6 mice, while mice infected ip with the 2 lowest doses were essentially equivalent in resistance. Thus, the difference in susceptibility was detectable, in terms of parasitemia levels and survival, primarily at the higher infection doses. For the groups infected sc, the pattern of susceptibility reversed. B6 mice infected with the 3 highest doses had lower parasitemia levels than the corresponding C3H mice, while C3H and B6 mice infected with 10(5) or 10(3) BFTs were similar in resistance. Blastogenic responses of lymphoid cells to phytohemagglutinin (PHA) and a soluble trypanosome extract (STE) were compared for C3H mice infected ip or sc to determine if the susceptibility to infection obtained with the 2 routes would be asso...Continue Reading

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