Relationship of Seminal Megavesicles, Prostate Median Cysts, and Genotype in Autosomal Dominant Polycystic Kidney Disease

Journal of Magnetic Resonance Imaging : JMRI
Weiguo ZhangMartin R Prince

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) can involve prostate and seminal vesicles but the potential interrelationship of these findings and associations with PKD gene mutation locus and type is unknown. To determine the interrelationship of seminal megavesicles (seminal vesicles with lumen diameter > 10mm) and prostatic cysts in ADPKD and to determine whether there are associations with PKD gene mutations. Retrospective, case control. Male ADPKD subjects (n = 92) with mutations in PKD1 (n = 71; 77%) or PKD2 (n = 21; 23%), and age/gender-matched controls without ADPKD (n = 92). 1.5T, axial/coronal T2 -weighted MR images. Reviewers blinded to genotype independently measured seminal vesicle lumen diameter and prevalence of cysts in prostate, kidney, and liver. Nonparametric tests for group comparisons and univariate and multivariable logistic regression analyses to identify associations of megavesicles and prostate median cysts with mutations and renal/hepatic cyst burden. Seminal megavesicles were found in 23 of 92 ADPKD (25%) subjects with PKD1 (22/71, 31%) or PKD2 (n = 1/21, 5%) mutations, but in only two control subjects (P < 0.0001). Prostate median cysts were found in 17/92 (18%) ADPKD subjects, compared with on...Continue Reading

References

Oct 1, 1991·Fertility and Sterility·J P Pryor, W F Hendry
Apr 17, 2007·Lancet·Vicente E TorresYves Pirson
Apr 24, 2007·AJR. American Journal of Roentgenology·Sean CurranJürgen Rademaker
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Elizabeth DicksPatrick S Parfrey
Mar 7, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Roser TorraJose Ballarin
Oct 24, 2008·Journal of the American Society of Nephrology : JASN·York PeiDavid Ravine
Oct 25, 2008·Annual Review of Medicine·Peter C Harris, Vicente E Torres
Mar 12, 2010·Advances in Chronic Kidney Disease·Yves Pirson
Feb 22, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Arlene B ChapmanJared J Grantham
Jun 13, 2012·Clinical and Experimental Nephrology·Tatsuya SuwabeKenmei Takaichi
Feb 23, 2013·Journal of the American Society of Nephrology : JASN·Emilie Cornec-Le GallYannick Le Meur
Jul 12, 2013·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Haytham M ShebelTarek El-Diasty
Jul 31, 2014·Journal of the American Society of Nephrology : JASN·York PeiMasoom A Haider
Dec 30, 2014·Clinical Imaging·Beatriu ReigMartin R Prince
Jan 30, 2016·Journal of the American Society of Nephrology : JASN·Christina M HeyerUNKNOWN HALT PKD and CRISP Investigators
Aug 3, 2017·Clinical Imaging·Zerwa FarooqMartin R Prince
Dec 6, 2017·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·William E BraunRobert W Schrier

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Jan 15, 2019·Journal of Magnetic Resonance Imaging : JMRI·Weiguo ZhangMartin R Prince

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