Relationship of skeletal muscle perfusion measured by contrast-enhanced ultrasonography to histologic microvascular density

Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine
Marc-André WeberWulf Hildebrandt

Abstract

The purpose of this study was to compare skeletal muscle perfusion measured by contrast-enhanced ultrasonography (CEUS) with microvascular density in muscle biopsies. Power Doppler sonography after intravenous bolus injection of Levovist (SH U 508A; Schering AG, Berlin, Germany) was used to examine perfusion of vastus lateralis muscle in 23 healthy volunteers. Local blood volume (B), blood flow velocity (v), and blood flow (f) were calculated by analyzing replenishment kinetics. CEUS perfusion was compared with vascularization of biopsy samples from vastus lateralis muscle. Subjects were selected such that their aerobic capacity (maximal oxygen uptake [VO(2)max]) per body weight ranged between 23 and 66 mL . min(-1) . kg(-1) to render a large variability of skeletal muscle capillarization. Moreover, subjects' venous blood hematocrit (Hkt) was determined to estimate the plasmatic intravascular volume fraction (1-Hkt=PVF) in which the microbubbles can distribute. Median capillary density was 331/mm(2) (range, 207-469/mm(2)), and median capillary fiber contacts (CFC) were 3.6 (range, 2.3-6.5). CFC was correlated with VO(2)max (r=0.59; P<.01). Among CEUS parameters, B showed the closest correlation to CFC (r=0.53; P<.01). When CFC ...Continue Reading

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Citations

Jan 16, 2007·Journal of Neurology·Marc-André WeberStefan Delorme
Mar 3, 2009·Annals of the New York Academy of Sciences·Marc-André Weber
Jun 16, 2011·Der Radiologe·M-A WeberM Krix
May 29, 2018·Der Radiologe·M JäschkeC Fischer
Aug 11, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Annelise L MenesesChristopher D Askew
Oct 24, 2008·Current Opinion in Rheumatology·Ulrich A Walker
Oct 13, 2011·Medicine and Science in Sports and Exercise·Noelle M SelkowSusan A Saliba
Mar 4, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Wen-Chau WuThomas F Floyd
Jan 1, 2011·Journal of Athletic Training·Yannick GuillodoAlain Saraux
Mar 26, 2013·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Noelle M SelkowSusan A Saliba
Sep 15, 2012·Cardiovascular Research·Mark J Post
Dec 17, 2014·Clinical Rheumatology·Young-Sil AnHyoun-Ah Kim
Nov 27, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Pierre KunzChristian Fischer
Oct 4, 2019·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Ron ClijsenMarco Barbero
Feb 26, 2008·Journal of Strength and Conditioning Research·W Jackson DavisW Bart Davis
Apr 25, 2007·European Radiology·Marc-André WeberStefan Delorme
Oct 21, 2016·Muscle & Nerve·Amir DoriCraig M Zaidman
Dec 30, 2009·Medical & Biological Engineering & Computing·Yael Ruschkewitz, Amit Gefen
Sep 27, 2007·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Marc-André WeberMarco Essig
Mar 31, 2021·Pediatric Radiology·Aikaterini NtouliaSusan J Back
May 28, 2021·Brain Pathology·Samuel MalartreYves Allenbach

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