Relationship of subgingival and salivary microbiota to gingival overgrowth in heart transplant patients following cyclosporin A therapy

Journal of Periodontology
Giuseppe Alexandre RomitoNoedir Antônio Groppo Stolf

Abstract

Severe gingival overgrowth (GO) is induced in patients taking cyclosporin A (CsA) following organ transplantation. Determining which patient will develop GO is still not possible. The purpose of this study was to establish an association between CsA and gingival overgrowth in heart transplant patients taking into account periodontal and microbiological conditions. Thirty patients (10 female, 20 male; range: 13 to 67 years; mean age: 44.89) undergoing CsA treatment were evaluated using the gingival index (GI), plaque index (PI), probing depth (PD), and clinical attachment level (CAL). Subgingival samples collected from the deepest site of each quadrant and saliva samples were submitted to microbial analysis. All patients had at least 12 teeth. Exclusion criteria were the use of antibiotics and/or having undergone periodontal treatment 6 months prior to the study. Patients were divided in two groups: with gingival (GO+) and without gingival overgrowth (GO-). There were no statistically significant differences between the GO+ and GO- groups when CsA dosage, time since transplant, GI, PI, PD, and CAL were compared. Microbiological examination of the subgingival samples detected the following microorganisms: Actinobacillus actinomyc...Continue Reading

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Citations

Jul 7, 2005·Journal of Clinical Periodontology·Mario AimettiCesare Debernardi
Sep 3, 2011·Journal of Clinical Periodontology·Bettina DannewitzClaudia Sommerer
Jul 14, 2010·Journal of Clinical Periodontology·Luís Otávio Miranda CotaFernando Oliveira Costa
Dec 17, 2014·Periodontology 2000·Adolfo ContrerasJørgen Slots
Oct 4, 2012·FEMS Microbiology Reviews·Elizabeth Carmel Murphy, Inga-Maria Frick
May 10, 2017·The Journal of Clinical Investigation·Leonardo V RiellaMaria-Luisa Alegre
Feb 16, 2020·British Dental Journal·M O Gruter, H S Brand
Jan 19, 2021·Journal of Oral and Maxillofacial Pathology : JOMFP·K NivethithaNina Shenoy

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