Relationship of T lymphocytes, cytokines, immunoglobulin E and nitric oxide with otitis media with effusion in children and their clinical significances

Revista da Associação Médica Brasileira
Wenyan FanWanpeng Li

Abstract

To investigate the relations of T lymphocytes, cytokines, immunoglobulin E, and nitric oxide with otitis media with effusion (OME) in children and their clinical significances. Fifty children with OME treated in our hospital were enrolled in the study (observation group). Fifty healthy children were selected as control. The percentages of CD4+ and CD8+ T lymphocyte and CD4+/CD8+ ratio in peripheral blood, and the levels of cytokine (IL)-2, IL-4, IL-6, immunoglobulin E (IgE) and nitric oxide (NO) in peripheral blood and middle ear effusion (MEE) in both groups were detected. The correlations of these indexes with OME were analyzed. The percentage of peripheral blood CD4+ and CD8+ levels, CD4+/CD8 ratio, IgE, and NO levels in the observation group were significantly higher than those in the control group (P < 0.01). In the observation group, the IL-2 and IL-6 levels, and IgE and NO levels in the MEE were significantly higher than those in peripheral blood (P < 0.01). In addition, in the observation group, the MEE IL-2 and IL-6 levels were positively correlated with peripheral blood CD4+/CD8+ ratio, respectively r = 0.366, P = 0.009; r = 0.334, P = 0.018. The levels of peripheral blood CD4+ and CD8+ lymphocytes and MEE IL-2, IL-6,...Continue Reading

References

May 1, 1994·The Annals of Otology, Rhinology & Laryngology. Supplement·J M Bernstein, W J Doyle
Aug 16, 2000·Clinical Otolaryngology and Allied Sciences·H KubbaJ P Birchall
Oct 5, 2002·International Journal of Pediatric Otorhinolaryngology·Chul-Ho Jang, Young-Ho Kim
May 7, 2004·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Karen Jo DoyleR Mark Ray
Jan 15, 2008·American Journal of Respiratory Cell and Molecular Biology·Lee J QuintonJoseph P Mizgerd
Jan 19, 2008·American Journal of Medical Genetics. Part a·Paola MarchisioNicola Principi
Mar 2, 2010·International Journal of Pediatric Otorhinolaryngology·Charles PudrithTimothy Jung
Oct 5, 2010·Clinical & Developmental Immunology·Mingli XuTakayuki Yoshimoto
Dec 15, 2010·International Journal of Pediatric Otorhinolaryngology·Michal KotowskiPatrycja Lachowska-Kotowska
Oct 6, 2011·Current Allergy and Asthma Reports·Francesco Martines, Daniela Bentivegna
Mar 3, 2012·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Beata Żelazowska-RutkowskaBożena Skotnicka
Mar 4, 2014·Clinical and Experimental Otorhinolaryngology·Youn Jung KimSeung Geun Yeo
May 20, 2014·Otolaryngologia polska. The Polish otolaryngology·Mohammed A GomaaYaser Makram Elsherbeny
Jan 19, 2018·The Journal of Laryngology and Otology·K AkazawaM Sakagami

❮ Previous
Next ❯

Citations

Jan 29, 2021·BioMed Research International·Zhenjie ZhangZhenghong Li

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Pakistan Journal of Medical Sciences
Zihe Zhang, Chunguang Wang
Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
Szilárd RezesIstván Sziklai
© 2021 Meta ULC. All rights reserved