Relationship of the angiotensin-converting enzyme gene polymorphism to glucose intolerance, insulin resistance, and hypertension in NIDDM

Human Genetics
X H HuangT Lehtimäki

Abstract

The deletion (D) allele of the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism has been shown to be associated with cardiovascular and renal diseases in diabetes mellitus, but the mechanism underlying this association is not known. In addition, recent studies of the effect of the ACE gene on blood pressure have yielded conflicting results. Therefore, we studied the association of the ACE gene I/D polymorphism with glucose intolerance and insulin resistance, and the contribution of this locus to genetic susceptibility to hypertension in non-insulin-dependent diabetic mellitus (NIDDM). We analysed the ACE genotype in 84 unrelated NIDDM patients with a known disease duration of less than 1 year and in 115 age- and sex-matched controls. The I/D polymorphism was determined by the polymerase chain reaction. There were no differences in ACE genotype distribution and allele frequencies between patients with NIDDM and nondiabetic controls. The frequencies of the D and I alleles in both groups were identical, viz., 0.65 and 0.35, respectively. The NIDDM patients with the DD genotype had significantly higher blood glucose levels in the oral glucose tolerance test than those with the other genotypes; the incr...Continue Reading

Citations

Dec 18, 2012·Current Hypertension Reports·Patricia C Underwood, Gail K Adler
Jun 22, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M C HsiehJ H Tsai
Sep 24, 2005·International Journal of Clinical Practice·I DegirmenciC Demirustu
Apr 20, 2006·Diabetes Research and Clinical Practice·Puneet Pal SinghSarabjit Mastana
Feb 1, 2008·Diabetes Care·Fabrice BonnetUNKNOWN European Group for the Study of Insulin Resistance Relationship Between Insulin Sensitivity and Cardiovascular Disease Risk
Jul 16, 2008·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R L CardosoN A de Souza e Silva
Apr 12, 2008·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Imen ArfaSonia Abdelhak
Jan 18, 2002·Journal of Applied Physiology·D E HurlbutB F Hurley
Mar 19, 2008·Molecular Biology Reports·Fulya AkinSukru Gur
Mar 16, 2012·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Chin-Fu HsiaoKwan-Dun Wu
Dec 6, 2006·Annals of Saudi Medicine·Mohsen Af El-Hazmi, Arjumand S Warsy

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.