PMID: 7539334Feb 1, 1995Paper

Relationship of the expression of the S20 and L34 ribosomal proteins to polyamine biosynthesis in Escherichia coli

The International Journal of Biochemistry & Cell Biology
C A PanagiotidisE S Canellakis

Abstract

Polyamine biosynthesis in Escherichia coli is regulated transcriptionally and post-translationally. Antizyme and ribosomal proteins S20 and L34 participate in post-translational inhibition of the polyamine biosynthetic enzymes ornithine and arginine decarboxylase. The aim of the present study was to investigate the significance of S20 and L34 in polyamine regulation in vivo. In vivo overexpression of S20 and L34 lowered the activities of ornithine and arginine decarboxylases and decreased total polyamine production. The levels of cadaverine, a related diamine whose synthesis is not regulated by S20 and L34, did not decrease but increased. The diminished ornithine and arginine decarboxylase activities are shown to result from reversible post-translational inhibition since the enzymes could be reactivated to normal levels upon titration of the inhibitors. The effects were specific as overexpression of eight other ribosomal proteins had no influence. Overexpression of ornithine decarboxylase results in elevated polyamine production and it increases S20 and L34 levels but not those of other ribosomal proteins. Ornithine depletion decreases S20 and L34 to normal levels in the ornithine decarboxylase overproducing cells. Immunoprecip...Continue Reading

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Citations

Jul 24, 2010·Human Genomics·Rital B BhavsarPanagiotis A Tsonis
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·O LunguS J Silverstein
Apr 26, 2008·Molecular BioSystems·Aram AdourianIna Schuppe-Koistinen
Jul 4, 2019·Amino Acids·Daniel Charlier, Indra Bervoets
Feb 15, 2000·International Reviews of Immunology·F W Chen, Y A Ioannou
Mar 2, 1999·Biochemical and Biophysical Research Communications·M Moorthamer, B Chaudhuri
Dec 1, 2004·EcoSal Plus·Daniel Charlier, Nicolas Glansdorff

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