PMID: 6158966May 1, 1980Paper

Relationship of total serum sialic acid to sialylglycoprotein acute-phase reactants in malignant melanoma

British Journal of Cancer
H K SilverF A Salinas

Abstract

Reported elevations of total serum sialic acid may be a result of shed tumour-related membrane sialyglycoprotein and/or concurrent elevation of non-specific, acute-phase reactant sialoglycoprotein. To clarify further the specificity and sensitivity of serum sialic acid monitoring, analyses of sialic acid by the thiobarbituric acid method and acute-phase reactants by radial immunodiffusion were made using the same malignant melanoma patients' sera. Preliminary studies of IgG, IgA, IgM, ceruloplasmin and C-reactive protein suggested that these would not be valuable monitors of tumour burden. Single serum samples from 59 melanoma patients and age- and sex-matched controls were further examined for sialic acid, alpha 1-acid glycoprotein, alpha 1-antitrypsin, haptoglobin, and alpha 2-macroglobulin. Patients were grouped according to tumour burden. In pairwise statistical tests, differences between groups tended to be greater for sialic acid than for acute-phase reactants. On discriminant analysis , sialic acid was clearly the most significant single discriminator between groups, with an F statistic of P < 0.00005. Although alpha 1-acid glycoprotein was quite strongly correlated with sialic acid, it was not such a good discriminator ...Continue Reading

Citations

Jan 15, 1983·International Journal of Cancer. Journal International Du Cancer·H K SilverJ J Spinelli
May 18, 2001·Journal of Chromatography. a·C J ShawB Xiao
Oct 28, 1983·Carbohydrate Research·Y HataeE A Davidson
Jul 15, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·P C DennyS E Allerton
Jan 1, 1984·Biochimica Et Biophysica Acta·L A Smets, W P Van Beek
Dec 16, 1991·Clinica Chimica Acta; International Journal of Clinical Chemistry·Z VéghB Szajáni
Jul 1, 1981·European Journal of Cancer & Clinical Oncology·A H Ryan, J J Fennelly
Jan 1, 1989·Critical Reviews in Oncology/hematology·J A Alhadeff

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