PMID: 9544897Apr 17, 1998Paper

Relationship of uric acid concentrations and severe intraventricular hemorrhage/leukomalacia in the premature infant

The Journal of Pediatrics
J M Perlman, R C Risser

Abstract

The purine metabolite hypoxanthine accumulates with hypoxia ischemia and with reperfusion is converted to uric acid (UA). We hypothesized that elevated UA concentration is a marker of previous hypoxia ischemia and would identify infants at greatest risk for having subsequent intraventricular hemorrhage (IVH)/periventricular leukomalacia (PVL). We determined the relationship between UA concentrations in the first postnatal day and the development of severe IVH, PVL, or both in 58 infants of birth weight 865 +/- 177 gm and gestational age 27 +/- 2 weeks. Severe IVH developed in 10 (17%) infants and PVL in 3 (5.1%) infants. UA concentrations on day 1 (obtained at 16 +/- 4 hours) were 7.9 +/- 2.8 mg/dl and increased to 9.5 +/- 2.58 mg/dl on day 2. UA concentrations on day 1 were higher in infants with severe IVH/PVL versus those in infants with neither condition: 10.2 vs 7.3 mg/dl (p = 0.005). Infants with hyperkalemia on the second postnatal day had higher UA concentrations on the first day versus infants with normal potassium levels: 11.7 +/- 2 mg/dl versus 6.8 +/- 1.8 mg/dl (p < 0.0005). Infants with severe IVH/PVL had higher potassium levels on day 2 versus infants with neither condition: 11.9 vs 6.9 mg/dl (p < 0.048). By univa...Continue Reading

References

Feb 1, 1985·Journal of Molecular and Cellular Cardiology·D E ChambersJ M Downey
Jun 1, 1996·The Journal of Pediatrics·W D Wilcox

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Citations

Jun 24, 2004·Archives of Disease in Childhood. Fetal and Neonatal Edition·B ReschB Pertl
Jul 1, 2006·Biology of the Neonate·Didem AliefendioğluAyşe Tana Aslan
Apr 29, 2014·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Maria AndrikopoulouIrina Burd
Nov 27, 2001·Brain & Development·A OkumuraK Watanabe
Mar 28, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·T C CalderonD M Angeles
Nov 26, 2009·Journal of Perinatology : Official Journal of the California Perinatal Association·A A Wanderer
Jan 9, 2003·Clinics in Perinatology·Jennifer Grow, John D E Barks
May 10, 2000·Seminars in Neonatology : SN·F Groenendaal, L S de Vries
Jan 26, 2002·Pediatric Research·Diego GazzoloFabrizio Michetti
May 16, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Alan A Wanderer

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