Relationship of zolpidem and cancer risk: a Taiwanese population-based cohort study.

Mayo Clinic Proceedings
Chia-Hung KaoChih-Hsin Muo

Abstract

To evaluate the relationship between the use of zolpidem and subsequent cancer risk in Taiwanese patients. We used data from the National Health Insurance system of Taiwan to investigate whether use of zolpidem was related to cancer risk. For the study cohort, we identified 14,950 patients who had received a first prescription for zolpidem from January 1, 1998, through December 31, 2000. For each zolpidem user, we selected randomly 4 comparison patients without a history of using zolpidem who were frequency-matched by sex, age, and year of the index date. Incidence rates of all cancers and selected site-specific cancers were measured by the end of 2009, and related hazard ratios (HRs) and 95% confidence intervals (CIs) of the cancer were measured as well. The risk of developing any cancer was greater in patients using zolpidem than in nonusers (HR, 1.68; 95% CI, 1.55-1.82). The stratified analysis showed that the overall HR for high-dosage zolpidem (≥300 mg/y) was 2.38. The site-specific cancer risk was the highest for oral cancer (HR, 2.36; 95% CI, 1.57-3.56), followed by kidney cancer, esophageal cancer, breast cancer, liver cancer, lung cancer, and bladder cancer (HR, 1.60; 95% CI, 1.06-2.41). Men were at higher risk than wo...Continue Reading

References

May 1, 1991·The Journal of International Medical Research·D SchlichH J Kryrein
Nov 14, 2007·Primary Care Companion to the Journal of Clinical Psychiatry·Mari-Ann WallanderRoger Jones
Oct 11, 2008·Journal of Sleep Research·Daniel F Kripke
May 12, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Gregg S GagliardiAnthony J Dimarino
Jun 11, 2009·Journal of Clinical Neurology·Yong Won ChoChristopher J Earley
Jun 23, 2009·Journal of Cancer Research and Therapeutics·Noureen M Chocolatewala, Pankaj Chaturvedi
Jan 25, 2011·Pharmacoepidemiology and Drug Safety·Ane Birgitte Telén Andersen, Morten Frydenberg
Feb 8, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Ji-An LiangChia-Hung Kao
Apr 26, 2011·Japanese Journal of Clinical Oncology·Ji-An LiangChia-Hung Kao
Jul 16, 2011·Expert Opinion on Pharmacotherapy·F Xavier Bosch
May 5, 2012·Science·Gawain Kripke

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Citations

Apr 9, 2013·Clinical Obstetrics and Gynecology·Christopher R Jones
Aug 16, 2012·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Daniel F KripkeLawrence E Kline
Nov 14, 2015·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Daniel F Kripke
Aug 2, 2014·British Journal of Clinical Pharmacology·Anton PottegårdJesper Hallas
Jun 28, 2015·Sleep Medicine·Børge SivertsenJussi Vahtera
Mar 22, 2014·Sleep Disorders·Joseph V PergolizziManinder Chopra
Oct 29, 2014·Menopause : the Journal of the North American Menopause Society·Hrayr AttarianBarbara Phillips
Dec 11, 2014·Psychopharmacology·Shih-Wei LaiKuan-Fu Liao
Apr 8, 2015·European Journal of Clinical Pharmacology·C Ineke Neutel, Helen L Johansen
May 9, 2012·Mayo Clinic Proceedings·Barbara A Phillips
Aug 20, 2016·Journal of Clinical Pharmacology·Fan-Gen HsuShih-Wei Lai
Jun 10, 2017·British Journal of Clinical Pharmacology·Lau Caspar ThygesenJesper Hallas
Jul 6, 2018·Korean journal of family medicine·Do-Hyoung KimJa-Young Kim
Nov 26, 2015·F1000Research·Daniel F Kripke
Jul 31, 2018·Drugs & Aging·Vivien C Abad, Christian Guilleminault
Oct 7, 2020·Medicina·Tzu-Rong PengYou-Chen Chao
Nov 28, 2016·Cancer Cell·Nicole M KettnerLoning Fu

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