Abstract
To evaluate the relationship between the use of zolpidem and subsequent cancer risk in Taiwanese patients. We used data from the National Health Insurance system of Taiwan to investigate whether use of zolpidem was related to cancer risk. For the study cohort, we identified 14,950 patients who had received a first prescription for zolpidem from January 1, 1998, through December 31, 2000. For each zolpidem user, we selected randomly 4 comparison patients without a history of using zolpidem who were frequency-matched by sex, age, and year of the index date. Incidence rates of all cancers and selected site-specific cancers were measured by the end of 2009, and related hazard ratios (HRs) and 95% confidence intervals (CIs) of the cancer were measured as well. The risk of developing any cancer was greater in patients using zolpidem than in nonusers (HR, 1.68; 95% CI, 1.55-1.82). The stratified analysis showed that the overall HR for high-dosage zolpidem (≥300 mg/y) was 2.38. The site-specific cancer risk was the highest for oral cancer (HR, 2.36; 95% CI, 1.57-3.56), followed by kidney cancer, esophageal cancer, breast cancer, liver cancer, lung cancer, and bladder cancer (HR, 1.60; 95% CI, 1.06-2.41). Men were at higher risk than wo...Continue Reading
References
May 1, 1991·The Journal of International Medical Research·D SchlichH J Kryrein
Dec 1, 1996·International Clinical Psychopharmacology·J M MontiM Giusti
Sep 4, 1998·International Clinical Psychopharmacology·G Hajak, B Bandelow
Feb 7, 2006·Sleep Medicine·C M MorinC Mérette
Jun 30, 2007·Primary Care Companion to the Journal of Clinical Psychiatry·Joseph A Lieberman
Nov 14, 2007·Primary Care Companion to the Journal of Clinical Psychiatry·Mari-Ann WallanderRoger Jones
Oct 11, 2008·Journal of Sleep Research·Daniel F Kripke
Jan 8, 2009·International Journal of Geriatric Psychiatry·Kristina Johnell, Johan Fastbom
May 12, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Gregg S GagliardiAnthony J Dimarino
Jun 11, 2009·Journal of Clinical Neurology·Yong Won ChoChristopher J Earley
Jun 23, 2009·Journal of Cancer Research and Therapeutics·Noureen M Chocolatewala, Pankaj Chaturvedi
Dec 10, 2009·Cancer·Brenda K EdwardsLynn A G Ries
Jan 25, 2011·Pharmacoepidemiology and Drug Safety·Ane Birgitte Telén Andersen, Morten Frydenberg
Feb 8, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Ji-An LiangChia-Hung Kao
Apr 26, 2011·Japanese Journal of Clinical Oncology·Ji-An LiangChia-Hung Kao
Jul 16, 2011·Expert Opinion on Pharmacotherapy·F Xavier Bosch
May 5, 2012·Science·Gawain Kripke
Citations
Apr 9, 2013·Clinical Obstetrics and Gynecology·Christopher R Jones
Sep 15, 2012·BMJ Open·Arthur Hartz, John Jacob Ross
Aug 16, 2012·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Daniel F KripkeLawrence E Kline
Feb 6, 2016·BMC Cancer·Victor C KokChun-Hung Tseng
Nov 14, 2015·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Daniel F Kripke
Jan 10, 2014·Annals of Epidemiology·Li-Yu HuChia-Jen Liu
Oct 6, 2012·Mayo Clinic Proceedings·Aaron S Geller
Sep 25, 2015·Medicine·Chia-Ling LinChia-Hung Kao
Aug 2, 2014·British Journal of Clinical Pharmacology·Daniel F Kripke, Robert D Langer
Aug 2, 2014·British Journal of Clinical Pharmacology·Anton PottegårdJesper Hallas
Jun 28, 2015·Sleep Medicine·Børge SivertsenJussi Vahtera
Mar 22, 2014·Sleep Disorders·Joseph V PergolizziManinder Chopra
Jun 16, 2012·Gynecologic Oncology·Li-Min SunChia-Hung Kao
Oct 29, 2014·Menopause : the Journal of the North American Menopause Society·Hrayr AttarianBarbara Phillips
Dec 11, 2014·Psychopharmacology·Shih-Wei LaiKuan-Fu Liao
Apr 8, 2015·European Journal of Clinical Pharmacology·C Ineke Neutel, Helen L Johansen
Sep 23, 2014·Mayo Clinic Proceedings·Barry KrakowNatalia D McIver
May 9, 2012·Mayo Clinic Proceedings·Barbara A Phillips
May 8, 2016·BioMedicine·Shih-Wei Lai
Aug 20, 2016·Journal of Clinical Pharmacology·Fan-Gen HsuShih-Wei Lai
Dec 29, 2015·PloS One·Tzuo-Yun LanHsiao-Feng Ho
Jun 10, 2017·British Journal of Clinical Pharmacology·Lau Caspar ThygesenJesper Hallas
Sep 3, 2017·Drugs in R&D·Jaden Brandt, Christine Leong
Jul 6, 2018·Korean journal of family medicine·Do-Hyoung KimJa-Young Kim
Nov 26, 2015·F1000Research·Daniel F Kripke
Jun 16, 2016·F1000Research·Daniel F Kripke
Nov 27, 2019·Medicine·Shih-Wei LaiKuan-Fu Liao
May 19, 2016·F1000Research·Daniel F Kripke
Feb 1, 2020·Oncoimmunology·Anne-Sophie HamyFabien Reyal
Jul 31, 2018·Drugs & Aging·Vivien C Abad, Christian Guilleminault
Oct 7, 2020·Medicina·Tzu-Rong PengYou-Chen Chao
Nov 28, 2016·Cancer Cell·Nicole M KettnerLoning Fu