Relationship uncertainty linkage statistics (RULS): affected relative pair statistics that model relationship uncertainty

Genetic Epidemiology
Amrita Ray, Daniel E Weeks

Abstract

Linkage analysis programs invariably assume that the stated familial relationships are correct. Thus, it is common practice to resolve relationship errors by either discarding individuals with erroneous relationships or using an inferred alternative pedigree structure. These approaches are less than ideal because discarding data is wasteful and using inferred data can be statistically unsound. We have developed two linkage statistics that model relationship uncertainty by weighting over the possible true relationships. Simulations of data containing relationship errors were used to assess our statistics and compare them to the maximum-likelihood statistic (MLS) and the Sall non-parametric LOD score using true and discarded (where problematic individuals with erroneous relationships are discarded from the pedigree) structures. We simulated both small pedigree (SP) and large pedigree (LP) data sets typed genome-wide. Both data sets have several underlying true relationships; SP has one apparent relationship--full sibling--and LP has several different apparent relationship types. The results show that for both SP and LP, our relationship uncertainty linkage statistics (RULS) have power nearly as high as the MLS and Sall using the ...Continue Reading

References

Jan 1, 1988·Genetic Epidemiology·K LangeM Boehnke
Jul 1, 1971·Annals of Human Genetics·J W James
Aug 1, 1997·American Journal of Human Genetics·M Boehnke, N J Cox
Dec 1, 1999·American Journal of Human Genetics·J M Olson
Mar 11, 2000·American Journal of Human Genetics·M S McPeek, L Sun
Mar 23, 2000·American Journal of Human Genetics·H J CordellR C Elston
Dec 4, 2001·Nature Genetics·Gonçalo R AbecasisLon R Cardon
Oct 30, 2004·American Journal of Human Genetics·Kathleen A DalyStephen S Rich
Oct 1, 2005·Nature Genetics·Daniel F GudbjartssonAnna Ingolfsdottir
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Dvora ShmulewitzJeffrey M Friedman

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