Abstract
The associations among autonomic neuropathy, urinary albumin excretion, and glomerular filtration rate (GFR) measured with 51Cr-EDTA and iohexol clearance were studied in 41 patients with insulin-dependent diabetes mellitus (IDDM) and 15 patients with non-insulin-dependent diabetes mellitus (NIDDM). The study showed that increased urinary albumin excretion was more common in NIDDM than in IDDM. In contrast with IDDM, albuminuria in NIDDM was not related to GFR. Autonomic neuropathy was common in IDDM as well as in NIDDM, and also in patients without nephropathy, but was not connected with hyperfiltration. Low brake index, an ortostatic autonomic index, was associated with nephropathy in NIDDM. Iohexol, a non-ionic contrast medium, was found to be a useful alternative to 51Cr-EDTA for determination of GFR. Moreover, comparison between conventional four-sample plasma clearance and single-sample clearance showed a close correlation. Accordingly, assessment of GFR using a single plasma sample provides reliable results even at high GFR values.
References
Apr 7, 1979·British Medical Journal·G SundkvistB Lilja
Jun 7, 1975·British Medical Journal·M Fisher, N Veall
Jun 1, 1977·Diabetes·D M FraserB F Clarke
Apr 1, 1992·Kidney International·J P VoraJ R Peters
Jul 1, 1992·Diabetes·H MølgaardC E Mogensen
Sep 1, 1991·The Journal of Urology·S C Brown, P H O'Reilly
Dec 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·A W PatrickB M Frier
Apr 1, 1990·Scandinavian Journal of Clinical and Laboratory Investigation·G StakeT Monclair
Jan 1, 1990·Journal of Internal Medicine·B BergströmG Sundkvist
Mar 1, 1989·Journal of Internal Medicine·B BergströmI Mattiasso
Apr 1, 1989·Diabetes Care·E ZanderH D Gottschling
Jun 1, 1989·Clinical Physiology·B BergströmG Sundkvist
Apr 1, 1988·Diabetes·D J BallardP J Palumbo
Jan 1, 1987·Acta Medica Scandinavica·B BergströmG Sundkvist
Nov 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation·J Bröchner-Mortensen
Jun 26, 1982·Lancet·G C VibertiH Keen
Aug 1, 1983·Clinical Physiology·L Jacobsson
Feb 9, 1984·The New England Journal of Medicine·C E Mogensen
Jul 12, 1984·The New England Journal of Medicine·C E Mogensen, C K Christensen
Oct 1, 1981·Scandinavian Journal of Clinical and Laboratory Investigation·G Granerus, M Aurell
May 1, 1982·Kidney International·C E Mogensen
May 1, 1982·Kidney International·J FabreA T Vernet
Nov 1, 1980·Diabetologia·G SundkvistL O Almér
Apr 1, 1995·Diabetic Medicine : a Journal of the British Diabetic Association·M D Flynn, J E Tooke
Dec 1, 1994·Diabetes Care·E A McDaidJ A Allen
Jun 1, 1994·Diabetes Care·V SpalloneG Menzinger
May 1, 1993·Diabetes Care·G Sundkvist, B Lilja
Nov 1, 1995·Diabetic Medicine : a Journal of the British Diabetic Association·H NilssonG Sundkvist