Relationships among physical inactivity, deconditioning, and walking impairment in persons with multiple sclerosis

Journal of Neurologic Physical Therapy : JNPT
Brian M SandroffRobert W Motl

Abstract

We have previously proposed a conceptual model of physical inactivity, physiological deconditioning, and walking impairment in persons with multiple sclerosis (MS) that suggests engaging in physical activity and improving physiological conditioning may lead to improvements in walking performance. This cross-sectional study examined the nature of associations among physical activity, aerobic capacity, and walking performance in persons with MS and healthy controls. The sample included 31 persons with MS and 31 controls matched by age, sex, height, and weight. Participants completed the 6-minute walk (6MW), wore an ActiGraph model GT3X accelerometer for 7 days as an objective measure of physical activity (expressed as time spent in moderate-to-vigorous physical activity [MVPA]), and completed an incremental exercise test on a cycle ergometer as a measure of aerobic capacity (VO2peak). Hierarchical linear regression analyses indicated that MVPA and VO2peak partially explained group differences in 6MW performance (R = 0.782), although group remained a significant predictor of 6MW performance (β = 0.304; P < 0.001). Path analysis indicated that group had both statistically significant direct and indirect effects on 6MW performance, ...Continue Reading

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Citations

Jan 20, 2016·Neurodegenerative Disease Management·Robert W MotlRalph H B Benedict
Oct 18, 2016·Scandinavian Journal of Medicine & Science in Sports·E SebastiãoR W Motl
Feb 17, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Robert W MotlUNKNOWN Multiple Sclerosis Outcome Assessments Consortium
Mar 7, 2017·Journal of Neurologic Physical Therapy : JNPT·Robert W MotlElizabeth A Hubbard
May 18, 2018·Expert Review of Neurotherapeutics·Jessica F BairdRobert W Motl
Sep 8, 2017·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Thomas EdwardsLara A Pilutti
Sep 19, 2017·Journal of Neurologic Physical Therapy : JNPT·Kathleen J ManellaEdelle C Field-Fote
May 3, 2019·International Journal of MS Care·Rachel E Bollaert, Robert W Motl
Aug 14, 2020·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·A A GevorkyanV Yu Lizhdvoy
May 12, 2018·Acta Neurologica Scandinavica·E Sebastião, R W Motl
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Dec 3, 2020·International Journal of Environmental Research and Public Health·Massimiliano PauEleonora Cocco
Sep 30, 2021·Physiotherapy Research International : the Journal for Researchers and Clinicians in Physical Therapy·Moira SmithRuth Barker

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