Abstract
Red cell distribution width (RDW) is known to be associated with anemia and mortality in cardiovascular diseases, while anemia itself is related to increased mortality. RDW may also be related to cytokine activation. We investigated the potential of RDW to predict anemia-adjusted mortality in patients with adult congenital heart disease (ACHD) and we evaluated the relationships among RDW, anemia, and interleukin-6 (IL-6). This was a single-center, retrospective cohort study. Blood RDW and IL-6 levels were measured in 144 patients with ACHD (median age [interquartile range (IQR)], 28 [22-36] years), 84% in New York Heart Association class I/II. During a mean 4.8-year follow-up, 21 (15%) patients died of cardiovascular causes. Elevated RDW (>15.0%) correlated significantly with mortality risk in a univariate analysis (RDW hazard ratio [HR]: 1.570; 95% confidence interval [CI]: 1.208-2.040 per 1 standard deviation increase; P=0.001). Elevated RDW levels correlated significantly with increased anemia-adjusted mortality (adjusted RDW HR: 1.912; 95% CI: 1.369-2.670; P<0.001). The high RDW group had significantly elevated serum IL-6 levels (RDW >15%, median [IQR], 3.7 [0.9-13.9] pg/ml vs. RDW ≤15%, 1.4 [0.8-2.5 pg/ml]; P=0.001), as di...Continue Reading
References
Sep 1, 1983·American Journal of Clinical Pathology·J D BessmanF H Gardner
May 1, 1996·Pediatric Cardiology·L OlcayA Celiker
Jul 3, 2002·Circulation·Aidan P BolgerMichael A Gatzoulis
Mar 7, 2003·Indian Journal of Pediatrics·Cemile Banu OnurAysel Yoney
Apr 26, 2003·European Heart Journal·Aidan P BolgerMichael A Gatzoulis
Sep 18, 2004·The American Journal of Cardiology·Harald KaemmererJohn Hess
Mar 11, 2005·The New England Journal of Medicine·Guenter Weiss, Lawrence T Goodnough
Jul 18, 2006·Journal of the American College of Cardiology·Craig S BrobergMichael A Gatzoulis
Jul 3, 2007·Journal of the American College of Cardiology·G Michael FelkerUNKNOWN CHARM Investigators
May 16, 2008·The New England Journal of Medicine·Eugene Braunwald
Sep 29, 2009·American Heart Journal·Zsolt FörhéczLívia Jánoskuti
Nov 3, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kushang V PatelJack M Guralnik
Nov 21, 2009·European Journal of Heart Failure·Yahya Al-NajjarAndrew L Clark
Mar 9, 2010·Journal of Cardiac Failure·Larry A AllenKirkwood F Adams
Feb 8, 2011·The American Journal of Cardiology·Craig S BrobergMichael A Gatzoulis
May 11, 2011·International Journal of Cardiology·Domingo A Pascual-FigalJames L Januzzi
Sep 24, 2011·European Journal of Heart Failure·Yan BornéGunnar Engström
Oct 29, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Jaewon OhNamsik Chung
Feb 9, 2012·Pediatric Cardiology·Martial M Massin
Feb 22, 2012·The American Journal of Medicine·Sabina HunzikerMichael D Howell
Mar 29, 2012·International Journal of Laboratory Hematology·V DopsajD Kalimanovska-Ostric
May 9, 2012·International Journal of Cardiology·Badira F MakhoulZaher S Azzam
Aug 16, 2012·Congenital Heart Disease·Efrén Martínez-Quintana, Fayna Rodríguez-González
Oct 19, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Shuta TsuboiHiroyuki Daida
Jan 2, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Richard WarwickMichael Poullis
Jan 29, 2013·International Journal of Cardiology·Nay AungDarlington O Okonko
Jun 6, 2013·Heart·Nay AungPhilip A Maccarthy
Nov 28, 2013·Heart Failure Clinics·Hideo Ohuchi, Gerhard-Paul Diller
Dec 3, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·Julio NúñezJuan Sanchis
Apr 5, 2014·Journal of cardiology·Lidia Tomkiewicz-PajakPiotr Podolec
Citations
Mar 27, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Ryo Inuzuka, Jun Abe
Oct 11, 2017·British Journal of Biomedical Science·X ZhuX Qin
Dec 15, 2017·BMC Nephrology·Yueh-An LuChih-Hsiang Chang
Feb 23, 2020·Thoracic Cancer·Fangfang WuHongjun Gao
Mar 6, 2018·Medicine·Xubing ZhangZiqiang Wang
Oct 5, 2016·Experimental and Therapeutic Medicine·Hui-Bing ZhangShi-Yan Zhang
Sep 19, 2019·World Journal of Gastroenterology : WJG·Fang-Xiao ZhangXiao-Chun Ma
Apr 4, 2018·Pediatrics in Review·Melissa Kaori Silva Litao, Deepak Kamat
Feb 9, 2017·Journal of Clinical Laboratory Analysis·Derya GuzelAtila Erol
Apr 23, 2017·Current Cardiology Reports·Saurabh RajpalAlexander R Opotowsky
Nov 13, 2019·BMC Cancer·Manman LiShudao Xiong
Jun 8, 2017·Medicine·Hui XuYan-Xiang Pan
Nov 4, 2020·Bioscience Reports·Yingkun RenPeijun Wang
Dec 3, 2021·Heart Failure Reviews·Laura M WieneckeBenjamin G Chousterman