Relationships among red cell distribution width, anemia, and interleukin-6 in adult congenital heart disease

Circulation Journal : Official Journal of the Japanese Circulation Society
Kenji MiyamotoToshio Nakanishi

Abstract

Red cell distribution width (RDW) is known to be associated with anemia and mortality in cardiovascular diseases, while anemia itself is related to increased mortality. RDW may also be related to cytokine activation. We investigated the potential of RDW to predict anemia-adjusted mortality in patients with adult congenital heart disease (ACHD) and we evaluated the relationships among RDW, anemia, and interleukin-6 (IL-6). This was a single-center, retrospective cohort study. Blood RDW and IL-6 levels were measured in 144 patients with ACHD (median age [interquartile range (IQR)], 28 [22-36] years), 84% in New York Heart Association class I/II. During a mean 4.8-year follow-up, 21 (15%) patients died of cardiovascular causes. Elevated RDW (>15.0%) correlated significantly with mortality risk in a univariate analysis (RDW hazard ratio [HR]: 1.570; 95% confidence interval [CI]: 1.208-2.040 per 1 standard deviation increase; P=0.001). Elevated RDW levels correlated significantly with increased anemia-adjusted mortality (adjusted RDW HR: 1.912; 95% CI: 1.369-2.670; P<0.001). The high RDW group had significantly elevated serum IL-6 levels (RDW >15%, median [IQR], 3.7 [0.9-13.9] pg/ml vs. RDW ≤15%, 1.4 [0.8-2.5 pg/ml]; P=0.001), as di...Continue Reading

References

Sep 1, 1983·American Journal of Clinical Pathology·J D BessmanF H Gardner
Mar 7, 2003·Indian Journal of Pediatrics·Cemile Banu OnurAysel Yoney
Apr 26, 2003·European Heart Journal·Aidan P BolgerMichael A Gatzoulis
Mar 11, 2005·The New England Journal of Medicine·Guenter Weiss, Lawrence T Goodnough
Jul 18, 2006·Journal of the American College of Cardiology·Craig S BrobergMichael A Gatzoulis
Jul 3, 2007·Journal of the American College of Cardiology·G Michael FelkerUNKNOWN CHARM Investigators
May 16, 2008·The New England Journal of Medicine·Eugene Braunwald
Nov 3, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kushang V PatelJack M Guralnik
Nov 21, 2009·European Journal of Heart Failure·Yahya Al-NajjarAndrew L Clark
May 11, 2011·International Journal of Cardiology·Domingo A Pascual-FigalJames L Januzzi
Oct 29, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Jaewon OhNamsik Chung
Feb 22, 2012·The American Journal of Medicine·Sabina HunzikerMichael D Howell
Mar 29, 2012·International Journal of Laboratory Hematology·V DopsajD Kalimanovska-Ostric
May 9, 2012·International Journal of Cardiology·Badira F MakhoulZaher S Azzam
Aug 16, 2012·Congenital Heart Disease·Efrén Martínez-Quintana, Fayna Rodríguez-González
Oct 19, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Shuta TsuboiHiroyuki Daida
Jan 2, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Richard WarwickMichael Poullis
Nov 28, 2013·Heart Failure Clinics·Hideo Ohuchi, Gerhard-Paul Diller
Dec 3, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·Julio NúñezJuan Sanchis
Apr 5, 2014·Journal of cardiology·Lidia Tomkiewicz-PajakPiotr Podolec

❮ Previous
Next ❯

Citations

Mar 27, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Ryo Inuzuka, Jun Abe
Sep 19, 2019·World Journal of Gastroenterology : WJG·Fang-Xiao ZhangXiao-Chun Ma
Apr 4, 2018·Pediatrics in Review·Melissa Kaori Silva Litao, Deepak Kamat
Feb 9, 2017·Journal of Clinical Laboratory Analysis·Derya GuzelAtila Erol
Apr 23, 2017·Current Cardiology Reports·Saurabh RajpalAlexander R Opotowsky
Dec 3, 2021·Heart Failure Reviews·Laura M WieneckeBenjamin G Chousterman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.