Relationships among severity of osteonecrosis, pain, range of motion, and functional mobility in children, adolescents, and young adults with acute lymphoblastic leukemia

Physical Therapy
Victoria G MarcheseSue C Kaste

Abstract

Up to 38% of children receiving treatment for acute lymphoblastic leukemia (ALL) develop osteonecrosis, often without symptoms. Little is known about the association between the degree of osteonecrosis and functional mobility in this population. The purpose of this study was to examine relationships among the degree of osteonecrosis, pain, range of motion (ROM), and functional mobility in people with ALL. Thirty-three subjects aged 5 to 27 years with ALL and osteonecrosis participated. The extent of osteonecrosis was determined by magnetic resonance imaging (MRI) of the hip and knee according to 2 classification systems, including the Association Research Circulation Osseous (ARCO) and a knee staging scale. Pain, hip and knee ROM, and the Timed Up and Down Stairs (TUDS) Test were used as measures. Correlations were observed between ARCO and hip pain (r=.34), between hip flexion ROM and hip pain (r=-.34), and between knee pain and time on the TUDS Test (r=-.35). Physical therapists should consider that people with ALL may have hip or knee osteonecrosis without clinical symptoms. This notion supports the need for MRI in addition to a comprehensive examination of functional mobility.

References

Jan 1, 1991·Acta Oncologica·N HaimE Robinson
Jan 1, 1988·Journal of Biomechanics·B J McFadyen, D A Winter
Jul 1, 1986·AJR. American Journal of Roentgenology·M D MitchellL Axel
Jan 1, 1984·Skeletal Radiology·A M Schwartz, J C Leonidas
Jul 1, 1996·Annals of Internal Medicine·K ShanJ B Young
Aug 18, 1997·Pediatric Radiology·B D Fletcher
Jul 29, 1998·Medical and Pediatric Oncology·M J WrightR D Barr
Jan 26, 1999·Clinical Orthopaedics and Related Research·P BizotL Sedel
Nov 26, 1999·Medical and Pediatric Oncology·H Reinders-MesselinkW Kamps
Sep 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L A MattanoJ B Nachman
Sep 27, 2000·The Journal of Bone and Joint Surgery. American Volume·M A MontD S Hungerford
Jan 4, 2001·International Journal of Nursing Studies·D ArthurT Wong
Jan 30, 2003·Medical and Pediatric Oncology·Victoria Gocha MarcheseBeverly J Lange
Feb 7, 2003·The Journal of Bone and Joint Surgery. American Volume·Sebastian F CherianEdward Y Cheng
Jan 31, 2004·Pediatric Blood & Cancer·Victoria G MarcheseBeverly J Lange
Nov 3, 2005·Annals of Internal Medicine·Kirsten K NessJames G Gurney
Jan 13, 2006·The New England Journal of Medicine·Ching-Hon Pui, William E Evans
Jan 21, 2006·AJR. American Journal of Roentgenology·Evguenia J KarimovaSue C Kaste
Jan 21, 2006·AJR. American Journal of Roentgenology·Evguenia J KarimovaSue C Kaste
Oct 24, 2006·Pediatric Physical Therapy : the Official Publication of the Section on Pediatrics of the American Physical Therapy Association·Marilyn J WrightRonald D Barr
Oct 24, 2006·Pediatric Physical Therapy : the Official Publication of the Section on Pediatrics of the American Physical Therapy Association·Christopher A ZainoSarah L Westcott

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Citations

Aug 20, 2010·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Masaaki KuribayashiToshikazu Kubo
Nov 18, 2011·Pediatric Physical Therapy : the Official Publication of the Section on Pediatrics of the American Physical Therapy Association·Russell GeyerLaura Cooks
Apr 23, 2011·AJR. American Journal of Roentgenology·Sue C KasteMichael D Neel
Jan 17, 2009·Physical Therapy·Laura S GilchristKirsten K Ness
Aug 25, 2009·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Andrea TendasPaolo de Fabritiis
Feb 20, 2016·Physiotherapy Research International : the Journal for Researchers and Clinicians in Physical Therapy·Paula VercherMansoo Ko
Dec 4, 2012·International Journal of Nursing Studies·Jeanne M EricksonKristin Stegenga
Jan 22, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sue C KasteScott C Howard
Aug 30, 2017·Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses·Amanda BettleJean Hughes
Jan 31, 2019·Acta Oncologica·Riitta NiinimäkiTuukka Niinimäki
Apr 7, 2010·Pediatric Hematology and Oncology·Shadi Farzin GoharMelanie Comito
Dec 30, 2014·Cancer Nursing·Katie Olson, Adrianna Amari
Jan 28, 2020·Seminars in Oncology Nursing·Lynn TannerJessica Sparrow
Apr 17, 2021·Pediatric Research·Regine SöntgerathMiriam Götte

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