PMID: 3761358Jan 1, 1986Paper

Relationships among sodium current, permeability, and Na activities in control and glucocorticoid-stimulated rabbit descending colon

The Journal of Membrane Biology
S M Thompson, J H Sellin

Abstract

Effects of a potent synthetic glucocorticoid, methylprednisolone (MP), on transepithelial Na transport were examined in rabbit descending colon. Current-voltage (I-V) relations of the amiloride-sensitive apical Na entry pathway were measured in colonic tissues of control and MP-treated (40 mg im for 2 days) animals. Tissues were bathed mucosally by solutions of various Na activities, (Na)m, ranging from 6.2 to 75.6 mM, and serosally by a high K solution. These I-V relations conformed to the "constant field" flux equation permitting determination of the permeability of the apical membrane to Na, PmNa, and the intracellular Na activity, (Na)c. The following empirical relations were observed for both control and MP-treated tissues: Na transport increases hyperbolically with increasing (Na)m obeying simple Michaelis-Mentin kinetics; PmNa decreased hyperbolically with increasing (Na)m, but was unrelated to individual variations in (Na)c; (Na)c increased hyperbolically with (Na)m; both spontaneous and steroid-stimulated variations in Na entry rate could be attributed entirely to parallel variations in PmNa at each mucosal Na activity. Comparison of these empirical, kinetic relations between control and MP-treated tissues revealed: ma...Continue Reading

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Citations

Jan 1, 1987·The Journal of Membrane Biology·W ClaussE Skadhauge
Apr 1, 1988·The Journal of Clinical Investigation·J H SellinE J Cragoe
Apr 1, 1991·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·C Lehmann, J Durand
Feb 19, 2002·The Journal of Physiology·S Vidyasagar, B S Ramakrishna
Nov 10, 1994·Biochimica Et Biophysica Acta·M L GruwelJ Schrader

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